Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 13686..14443 Replicon plasmid pR18.0830_82k
Accession NZ_CP100696
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name tacT Uniprot ID A0A4U8I7M5
Locus tag NL711_RS24100 Protein ID WP_000406363.1
Coordinates 13961..14443 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A4U8I6Z6
Locus tag NL711_RS24095 Protein ID WP_001195099.1
Coordinates 13686..13970 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS24065 (NL711_24065) 9909..10958 + 1050 WP_001534988.1 hypothetical protein -
NL711_RS24070 (NL711_24070) 11082..11267 - 186 Protein_13 resolvase -
NL711_RS24075 (NL711_24075) 11361..11555 + 195 Protein_14 DUF4158 domain-containing protein -
NL711_RS24080 (NL711_24080) 11892..12170 + 279 WP_000534855.1 colicin E3/pyocin S6 family cytotoxin -
NL711_RS24085 (NL711_24085) 12155..13117 - 963 WP_000145248.1 hypothetical protein -
NL711_RS24090 (NL711_24090) 13114..13374 - 261 WP_000929810.1 hypothetical protein -
NL711_RS24095 (NL711_24095) 13686..13970 + 285 WP_001195099.1 DUF1778 domain-containing protein Antitoxin
NL711_RS24100 (NL711_24100) 13961..14443 + 483 WP_000406363.1 GNAT family N-acetyltransferase Toxin
NL711_RS24105 (NL711_24105) 14448..14554 - 107 Protein_20 ethanolamine utilization protein EutE -
NL711_RS24110 (NL711_24110) 14827..15276 + 450 WP_000750479.1 hypothetical protein -
NL711_RS24120 (NL711_24120) 16643..17401 + 759 WP_000493752.1 4'-phosphopantetheinyl transferase superfamily protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81966 81966


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(30-149)

Antitoxin

(13-88)


Sequences


Toxin        


Download         Length: 161 a.a.        Molecular weight: 18085.66 Da        Isoelectric Point: 6.0789

>T251084 WP_000406363.1 NZ_CP100696:13961-14443 [Salmonella enterica subsp. enterica serovar Weltevreden]
MEISVTAPELLNEEHDLQQFDCGNDVLSDWLRRRAMKNQYLNASRTFVICPECTKRVVGYYSIATGSVSHDSLGRSLRQN
MPDPVPVVLLGRLAVDECTQGHSFGKWLLNDTVTRISNLADQVGIKAIMVHAIDEQAKTFYEYFGFVQSPISPNILFYKI

Download         Length: 483 bp


Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10950.45 Da        Isoelectric Point: 8.5309

>AT251084 WP_001195099.1 NZ_CP100696:13686-13970 [Salmonella enterica subsp. enterica serovar Weltevreden]
MQTTIRKSVRNNQINIRATDEERAVIDYAASLVSKNRTDFIIEKAVSEAQNIILDQRVFVLDDARYQAFIKQLEAPVQNT
EGRQRLMDVKPEWK

Download         Length: 285 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A4U8I7M5


Antitoxin

Source ID Structure
AlphaFold DB A0A4U8I6Z6

References