251081

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4448645..4449426 Replicon chromosome
Accession NZ_CP100695
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag NL711_RS21755 Protein ID WP_000626100.1
Coordinates 4448645..4449136 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NL711_RS21760 Protein ID WP_001110452.1
Coordinates 4449133..4449426 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS21725 (4444651) 4444651..4445736 - 1086 WP_000099893.1 DNA cytosine methyltransferase -
NL711_RS21730 (4445906) 4445906..4446400 - 495 WP_000622310.1 GNAT family N-acetyltransferase -
NL711_RS21735 (4446397) 4446397..4446690 - 294 WP_001110462.1 DUF1778 domain-containing protein -
NL711_RS21740 (4447014) 4447014..4447058 - 45 WP_079827815.1 hypothetical protein -
NL711_RS21745 (4447468) 4447468..4447545 + 78 Protein_4256 porin family protein -
NL711_RS21750 (4447645) 4447645..4448397 + 753 WP_000842409.1 non-specific acid phosphatase -
NL711_RS21755 (4448645) 4448645..4449136 - 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
NL711_RS21760 (4449133) 4449133..4449426 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NL711_RS21765 (4449743) 4449743..4449964 + 222 WP_043991167.1 hypothetical protein -
NL711_RS21770 (4450225) 4450225..4451100 + 876 WP_000921676.1 AraC family transcriptional regulator -
NL711_RS21775 (4451097) 4451097..4451384 + 288 WP_001269916.1 transcriptional regulator RtsB -
NL711_RS21780 (4451360) 4451360..4451560 - 201 WP_001534538.1 ATP-binding cassette domain-containing protein -
NL711_RS21785 (4451580) 4451580..4451782 + 203 Protein_4264 hypothetical protein -
NL711_RS21790 (4451790) 4451790..4452057 + 268 Protein_4265 hypothetical protein -
NL711_RS21795 (4452352) 4452352..4453257 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4424592..4451972 27380


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T251081 WP_000626100.1 NZ_CP100695:c4449136-4448645 [Salmonella enterica subsp. enterica serovar Weltevreden]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT251081 WP_001110452.1 NZ_CP100695:c4449426-4449133 [Salmonella enterica subsp. enterica serovar Weltevreden]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
AlphaFold DB A0A5I1DGA4

References