Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 4445906..4446690 | Replicon | chromosome |
| Accession | NZ_CP100695 | ||
| Organism | Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830 | ||
Toxin (Protein)
| Gene name | TacT2 | Uniprot ID | A0A3V7IAA7 |
| Locus tag | NL711_RS21730 | Protein ID | WP_000622310.1 |
| Coordinates | 4445906..4446400 (-) | Length | 165 a.a. |
Antitoxin (Protein)
| Gene name | TacA2 | Uniprot ID | A0A3V7IAB6 |
| Locus tag | NL711_RS21735 | Protein ID | WP_001110462.1 |
| Coordinates | 4446397..4446690 (-) | Length | 98 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL711_RS21720 (4441876) | 4441876..4444641 | - | 2766 | WP_001534530.1 | hypothetical protein | - |
| NL711_RS21725 (4444651) | 4444651..4445736 | - | 1086 | WP_000099893.1 | DNA cytosine methyltransferase | - |
| NL711_RS21730 (4445906) | 4445906..4446400 | - | 495 | WP_000622310.1 | GNAT family N-acetyltransferase | Toxin |
| NL711_RS21735 (4446397) | 4446397..4446690 | - | 294 | WP_001110462.1 | DUF1778 domain-containing protein | Antitoxin |
| NL711_RS21740 (4447014) | 4447014..4447058 | - | 45 | WP_079827815.1 | hypothetical protein | - |
| NL711_RS21745 (4447468) | 4447468..4447545 | + | 78 | Protein_4256 | porin family protein | - |
| NL711_RS21750 (4447645) | 4447645..4448397 | + | 753 | WP_000842409.1 | non-specific acid phosphatase | - |
| NL711_RS21755 (4448645) | 4448645..4449136 | - | 492 | WP_000626100.1 | GNAT family N-acetyltransferase | - |
| NL711_RS21760 (4449133) | 4449133..4449426 | - | 294 | WP_001110452.1 | DUF1778 domain-containing protein | - |
| NL711_RS21765 (4449743) | 4449743..4449964 | + | 222 | WP_043991167.1 | hypothetical protein | - |
| NL711_RS21770 (4450225) | 4450225..4451100 | + | 876 | WP_000921676.1 | AraC family transcriptional regulator | - |
| NL711_RS21775 (4451097) | 4451097..4451384 | + | 288 | WP_001269916.1 | transcriptional regulator RtsB | - |
| NL711_RS21780 (4451360) | 4451360..4451560 | - | 201 | WP_001534538.1 | ATP-binding cassette domain-containing protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4424592..4451972 | 27380 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 165 a.a. Molecular weight: 17836.70 Da Isoelectric Point: 7.2923
>T251080 WP_000622310.1 NZ_CP100695:c4446400-4445906 [Salmonella enterica subsp. enterica serovar Weltevreden]
MISAPEPLHAGHILTSFFCGVDSMDNWLKQRAMKNQITGASRTFVCCDSDSRVMAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPIEPMMLMVTLGDLV
GSAI
MISAPEPLHAGHILTSFFCGVDSMDNWLKQRAMKNQITGASRTFVCCDSDSRVMAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPIEPMMLMVTLGDLV
GSAI
Download Length: 495 bp
>T251080 NZ_CP100695:c4446400-4445906 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGATTTCTGCCCCTGAACCGCTTCACGCTGGGCATATCCTGACTTCGTTTTTCTGTGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGATTACTGGTGCGTCCCGTACCTTTGTTTGCTGTGACAGCGATTCTAGGGTAA
TGGCTTACTACTCGCTGGCCTCCAGCGCAGTGATGACGAATACCGCGCCGGGCCGCTTTCGCCGCAATATGCCCGATCCG
ATCCCGGTGGTGGTGCTGGGACGCCTAGCGGTGGATCAGTCTCTACATGGGCAGGGTGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTACGGGTTATTCAGGTGGCTGAGACTATCGGCATTCGCGGGATGCTGGTTCATGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGAGGGTGGGGTTTGAGCCATCGCCGATAGAGCCGATGATGTTGATGGTGACGTTGGGGGATTTAGTG
GGAAGTGCTATCTGA
ATGATTTCTGCCCCTGAACCGCTTCACGCTGGGCATATCCTGACTTCGTTTTTCTGTGGTGTGGATTCTATGGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGATTACTGGTGCGTCCCGTACCTTTGTTTGCTGTGACAGCGATTCTAGGGTAA
TGGCTTACTACTCGCTGGCCTCCAGCGCAGTGATGACGAATACCGCGCCGGGCCGCTTTCGCCGCAATATGCCCGATCCG
ATCCCGGTGGTGGTGCTGGGACGCCTAGCGGTGGATCAGTCTCTACATGGGCAGGGTGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTACGGGTTATTCAGGTGGCTGAGACTATCGGCATTCGCGGGATGCTGGTTCATGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGAGGGTGGGGTTTGAGCCATCGCCGATAGAGCCGATGATGTTGATGGTGACGTTGGGGGATTTAGTG
GGAAGTGCTATCTGA
Antitoxin
Download Length: 98 a.a. Molecular weight: 10898.59 Da Isoelectric Point: 10.5451
>AT251080 WP_001110462.1 NZ_CP100695:c4446690-4446397 [Salmonella enterica subsp. enterica serovar Weltevreden]
MPAANSMTIKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPDAYQAFLVRLDQAPAPN
AALRKTMQTPAPWEQKK
MPAANSMTIKRETLNLRIRPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPDAYQAFLVRLDQAPAPN
AALRKTMQTPAPWEQKK
Download Length: 294 bp
>AT251080 NZ_CP100695:c4446690-4446397 [Salmonella enterica subsp. enterica serovar Weltevreden]
ATGCCAGCCGCAAATAGTATGACTATTAAACGCGAAACGTTGAATCTGCGCATCAGGCCCGCCGAGCGCGATCTTATCGA
TCGTGCAGCGAAAGCCAGAGGGAAAAACCGTACTGATTTTGTGCTGGAAGCTGCCCGTGCTGCCGCAGAGGAAGCGTTGA
TTGAACAGCGCATCATTATGGCCGATCCCGATGCTTATCAGGCGTTTCTCGTCCGGCTGGATCAGGCCCCTGCGCCAAAC
GCCGCGCTGCGTAAAACCATGCAAACTCCCGCGCCGTGGGAACAGAAAAAATGA
ATGCCAGCCGCAAATAGTATGACTATTAAACGCGAAACGTTGAATCTGCGCATCAGGCCCGCCGAGCGCGATCTTATCGA
TCGTGCAGCGAAAGCCAGAGGGAAAAACCGTACTGATTTTGTGCTGGAAGCTGCCCGTGCTGCCGCAGAGGAAGCGTTGA
TTGAACAGCGCATCATTATGGCCGATCCCGATGCTTATCAGGCGTTTCTCGTCCGGCTGGATCAGGCCCCTGCGCCAAAC
GCCGCGCTGCGTAAAACCATGCAAACTCCCGCGCCGTGGGAACAGAAAAAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V7IAA7 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V7IAB6 |