Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 282618..284168 Replicon plasmid pRAHAQ01
Accession NC_015062
Organism Rahnella sp. Y9602

Toxin (Protein)


Gene name hipA Uniprot ID H8P0L7
Locus tag RAHAQ_RS23515 Protein ID WP_013577980.1
Coordinates 282618..283913 (-) Length 432 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag RAHAQ_RS23520 Protein ID WP_013577981.1
Coordinates 283917..284168 (-) Length 84 a.a.

Genomic Context

RAHAQ_RS23505RAHAQ_RS23510RAHAQ_RS23525RAHAQ_RS23535RAHAQ_RS23515RAHAQ_RS23520RAHAQ_RS23530RAHAQ_RS23540
Location: 278792..279679 (888 bp)
Type: Others
Protein ID: WP_013577978.1
Location: 280077..282554 (2478 bp)
Type: Others
Protein ID: WP_013577979.1
Location: 284376..285086 (711 bp)
Type: Others
Protein ID: WP_013577982.1
Location: 286621..288021 (1401 bp)
Type: Others
Protein ID: WP_014416613.1
Location: 282618..283913 (1296 bp)
Type: Toxin
Protein ID: WP_013577980.1
Location: 283917..284168 (252 bp)
Type: Antitoxin
Protein ID: WP_013577981.1
Location: 285097..286296 (1200 bp)
Type: Others
Protein ID: WP_013577983.1
Location: 288028..288900 (873 bp)
Type: Others
Protein ID: WP_013577985.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
RAHAQ_RS23505278792..279679+888WP_013577978.1LysR family transcriptional regulator-
RAHAQ_RS23510280077..282554+2478WP_013577979.1membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family-
RAHAQ_RS23515282618..283913-1296WP_013577980.1type II toxin-antitoxin system HipA family toxinToxin
RAHAQ_RS23520283917..284168-252WP_013577981.1helix-turn-helix domain-containing proteinAntitoxin
RAHAQ_RS23525284376..285086+711WP_013577982.1GntR family transcriptional regulator-
RAHAQ_RS23530285097..286296-1200WP_013577983.12-dehydro-3-deoxy-6-phosphogalactonate aldolase-
RAHAQ_RS23535286621..288021+1401WP_014416613.1PTS transporter subunit EIIC-
RAHAQ_RS23540288028..288900-873WP_013577985.1fumarylacetoacetate hydrolase family protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmidblaRAHN-2mgtB / vipA/tssB / vipB/tssC / hcp/tssD / clpV/tssH / hcp/tssD / hcp/tssD1..616549616549


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-64)


Sequences

Toxin        


Download         Length: 432 a.a.        Molecular weight: 48192.43 Da        Isoelectric Point: 7.0668

>T25108 WP_013577980.1 NC_015062:c283913-282618 [Rahnella sp. Y9602]
MDKLTLALNGIAVGTLEKGGSGEMSFVYHQSWLDRPGARAISLSLPLQADKFRGAVVYNFFDNLLPDNEQIRSRIQARFH
IPTKQPFDLLSRIGGDCVGAIQLYPEGDQVAPVTEIHAQPLGEKDIEQLLQGYKDAPLGMEADIEDFRISLAGAQEKTAL
LWYRDQWHRPQGSTPTSHILKLPIGYIANNGIDLSESVENEWLCLKIAEKFGFPVARSEIASFGAQKVLVVERFDRRWSQ
DGSWLMRLPQEDFCQALGVAPALKYESDGGPGIARAMKLLLGSQRAGADRDMFFKSQILFWMLAAIDGHAKNFSVYIEPG
SAYRMTPFYDVMSAFPLMHLQGIPAKKAKMAMAVLGKNRHFHWDRILPRHFVTTAQRVEYSKENVSAMMTEMKEKTEQVI
ADVEAIIPANFPAKISDAIFAGLRHQAARLP

Download         Length: 1296 bp

>T25108 NC_015062:c283913-282618 [Rahnella sp. Y9602]
ATGGATAAGTTAACGCTCGCATTAAATGGCATTGCTGTCGGTACCCTGGAAAAAGGCGGCAGTGGTGAAATGTCATTTGT
TTACCATCAAAGCTGGCTCGATCGCCCCGGAGCCCGCGCCATTTCATTATCATTACCTCTTCAGGCAGATAAATTCCGTG
GCGCAGTGGTATACAACTTTTTTGACAATCTTCTACCCGATAACGAACAGATACGCAGCCGTATTCAGGCACGTTTCCAC
ATCCCGACGAAGCAGCCTTTCGATTTGCTTTCGCGGATCGGTGGTGACTGTGTCGGTGCGATCCAGCTCTATCCTGAAGG
TGATCAGGTTGCACCTGTCACGGAAATTCATGCCCAACCGCTTGGCGAAAAGGATATTGAGCAGCTTCTGCAGGGATATA
AGGATGCACCTTTGGGCATGGAAGCTGACATTGAAGACTTTCGAATTTCTCTGGCCGGTGCACAGGAAAAAACGGCTTTG
CTCTGGTATCGCGACCAGTGGCATCGCCCGCAGGGAAGTACGCCTACCAGCCATATCCTTAAACTTCCTATTGGTTATAT
CGCTAACAATGGCATTGATCTCAGCGAGAGCGTGGAGAATGAATGGTTGTGTCTGAAGATAGCCGAAAAATTTGGATTTC
CTGTTGCACGGTCTGAGATTGCCAGTTTTGGCGCTCAGAAGGTGTTGGTCGTTGAGCGTTTTGACCGCCGCTGGTCGCAG
GATGGATCCTGGCTGATGCGTTTACCTCAGGAAGATTTTTGTCAGGCGCTGGGTGTTGCTCCCGCATTGAAGTATGAATC
TGATGGCGGCCCCGGAATTGCACGCGCAATGAAGCTTTTACTGGGTTCTCAACGGGCGGGGGCGGACAGGGATATGTTCT
TTAAAAGCCAGATCCTCTTCTGGATGCTGGCCGCCATTGACGGTCATGCTAAGAATTTCAGTGTTTATATCGAGCCGGGC
AGCGCATACCGCATGACACCGTTTTATGACGTGATGTCAGCATTTCCTCTGATGCATCTGCAAGGAATTCCGGCGAAGAA
AGCCAAAATGGCGATGGCTGTATTAGGGAAAAACCGGCATTTTCATTGGGACAGAATTCTTCCCCGCCATTTTGTGACGA
CGGCGCAACGGGTCGAGTACTCGAAAGAAAACGTCTCTGCGATGATGACGGAAATGAAGGAAAAAACTGAGCAGGTGATT
GCAGATGTTGAAGCAATAATACCTGCTAATTTTCCGGCAAAAATCAGTGATGCAATTTTTGCAGGCCTGCGCCATCAGGC
TGCACGTTTGCCTTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9570.88 Da        Isoelectric Point: 7.9783

>AT25108 WP_013577981.1 NC_015062:c284168-283917 [Rahnella sp. Y9602]
MNITSAKMLANALRNERKKRKLSQSKTAETIGLKQSTVSEFENYPDGTRLETLFKLLAALDLELQITPRDSNPQEKCTWD
QEW

Download         Length: 252 bp

>AT25108 NC_015062:c284168-283917 [Rahnella sp. Y9602]
ATGAACATTACATCTGCAAAAATGCTCGCCAATGCGCTGCGTAATGAGCGAAAAAAGCGCAAACTCAGCCAAAGTAAAAC
GGCTGAAACCATTGGCCTGAAGCAGTCTACGGTTTCTGAGTTCGAAAATTATCCGGACGGTACCCGTCTGGAAACACTGT
TCAAATTATTGGCGGCGCTGGATTTAGAGCTACAGATCACGCCAAGGGATAGCAATCCGCAGGAAAAGTGTACCTGGGAT
CAGGAGTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBH8P0L7

Antitoxin

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Source
ID
Structure
No matching records found

References