Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4296819..4297335 Replicon chromosome
Accession NZ_CP100695
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag NL711_RS21010 Protein ID WP_000220581.1
Coordinates 4296819..4297103 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL711_RS21015 Protein ID WP_000212724.1
Coordinates 4297093..4297335 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS20995 (4292030) 4292030..4293682 + 1653 WP_000155038.1 alpha,alpha-phosphotrehalase -
NL711_RS21000 (4294091) 4294091..4296229 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL711_RS21005 (4296351) 4296351..4296815 + 465 WP_001268862.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL711_RS21010 (4296819) 4296819..4297103 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL711_RS21015 (4297093) 4297093..4297335 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL711_RS21020 (4297413) 4297413..4299326 - 1914 WP_001212140.1 BglG family transcription antiterminator -
NL711_RS21025 (4299343) 4299343..4300083 - 741 WP_000779255.1 KDGP aldolase family protein -
NL711_RS21030 (4300080) 4300080..4301198 - 1119 WP_001139192.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL711_RS21035 (4301182) 4301182..4302315 - 1134 WP_000459951.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T251079 WP_000220581.1 NZ_CP100695:c4297103-4296819 [Salmonella enterica subsp. enterica serovar Weltevreden]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251079 WP_000212724.1 NZ_CP100695:c4297335-4297093 [Salmonella enterica subsp. enterica serovar Weltevreden]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References