251078

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4243373..4243923 Replicon chromosome
Accession NZ_CP100695
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name ccdB Uniprot ID M7RJ32
Locus tag NL711_RS20725 Protein ID WP_001199743.1
Coordinates 4243373..4243681 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V7ITQ8
Locus tag NL711_RS20730 Protein ID WP_000016244.1
Coordinates 4243684..4243923 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS20710 (4240855) 4240855..4240971 + 117 Protein_4054 transposase -
NL711_RS20715 (4241197) 4241197..4242216 - 1020 WP_001023050.1 IS110 family transposase -
NL711_RS20720 (4242283) 4242283..4243249 + 967 Protein_4056 IS3 family transposase -
NL711_RS20725 (4243373) 4243373..4243681 - 309 WP_001199743.1 CcdB family protein Toxin
NL711_RS20730 (4243684) 4243684..4243923 - 240 WP_000016244.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
NL711_RS20735 (4244036) 4244036..4244284 - 249 WP_000254752.1 ribbon-helix-helix domain-containing protein -
NL711_RS20740 (4244361) 4244361..4244516 - 156 Protein_4060 DUF4942 domain-containing protein -
NL711_RS20745 (4244507) 4244507..4245368 - 862 Protein_4061 IS630 family transposase -
NL711_RS20750 (4246146) 4246146..4247171 + 1026 WP_000369883.1 phage portal protein -
NL711_RS20755 (4247199) 4247199..4248869 - 1671 WP_000368629.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4241197..4257518 16321
- inside IScluster/Tn - - 4240855..4245323 4468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11845.67 Da        Isoelectric Point: 6.7228

>T251078 WP_001199743.1 NZ_CP100695:c4243681-4243373 [Salmonella enterica subsp. enterica serovar Weltevreden]
MQYMVYRNKGNSKAYPYLLDVQSDIIDELHTRMVIPLFPVSRLVNNPVKRLTPTLNVEGNDYLVMTHEMASIRLSQIGDE
VMDVRSHRQTIKNALDFIFDGF

Download         Length: 309 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8709.86 Da        Isoelectric Point: 6.4633

>AT251078 WP_000016244.1 NZ_CP100695:c4243923-4243684 [Salmonella enterica subsp. enterica serovar Weltevreden]
MSGMSVRHKKTVSVTLEPALLQQARDAGINLSAVLTAALKEEISATGVERWKAENRAGLQELNRITDEHGLLSDDYRTF

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6C6Z9V9

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5T4R8

References