251077

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4192338..4192914 Replicon chromosome
Accession NZ_CP100695
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NL711_RS20520 Protein ID WP_001131963.1
Coordinates 4192627..4192914 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag NL711_RS20515 Protein ID WP_000063143.1
Coordinates 4192338..4192640 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS20500 (4188849) 4188849..4190999 + 2151 WP_000379929.1 pyruvate/proton symporter BtsT -
NL711_RS20505 (4191094) 4191094..4191297 + 204 WP_000460616.1 YbdD/YjiX family protein -
NL711_RS20510 (4191308) 4191308..4192264 + 957 WP_000187837.1 GTPase -
NL711_RS20515 (4192338) 4192338..4192640 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
NL711_RS20520 (4192627) 4192627..4192914 - 288 WP_001131963.1 BrnT family toxin Toxin
NL711_RS20525 (4193183) 4193183..4194097 - 915 WP_000290515.1 restriction endonuclease -
NL711_RS20530 (4194295) 4194295..4197804 + 3510 WP_001043490.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T251077 WP_001131963.1 NZ_CP100695:c4192914-4192627 [Salmonella enterica subsp. enterica serovar Weltevreden]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT251077 WP_000063143.1 NZ_CP100695:c4192640-4192338 [Salmonella enterica subsp. enterica serovar Weltevreden]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References