Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3582040..3582660 Replicon chromosome
Accession NZ_CP100695
Organism Salmonella enterica subsp. enterica serovar Weltevreden strain R18.0830

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL711_RS17685 Protein ID WP_001280991.1
Coordinates 3582442..3582660 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL711_RS17680 Protein ID WP_000344807.1
Coordinates 3582040..3582414 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL711_RS17670 (3577179) 3577179..3578372 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL711_RS17675 (3578395) 3578395..3581544 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL711_RS17680 (3582040) 3582040..3582414 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL711_RS17685 (3582442) 3582442..3582660 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL711_RS17690 (3582839) 3582839..3583390 + 552 WP_001278793.1 maltose O-acetyltransferase -
NL711_RS17695 (3583508) 3583508..3583978 + 471 WP_000136183.1 YlaC family protein -
NL711_RS17700 (3584034) 3584034..3584174 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL711_RS17705 (3584176) 3584176..3584439 - 264 WP_000801422.1 type B 50S ribosomal protein L31 -
NL711_RS17710 (3584664) 3584664..3586214 + 1551 WP_000213145.1 EAL domain-containing protein -
NL711_RS17720 (3586445) 3586445..3586834 + 390 WP_000961285.1 MGMT family protein -
NL711_RS17725 (3586867) 3586867..3587436 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251074 WP_001280991.1 NZ_CP100695:3582442-3582660 [Salmonella enterica subsp. enterica serovar Weltevreden]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251074 WP_000344807.1 NZ_CP100695:3582040-3582414 [Salmonella enterica subsp. enterica serovar Weltevreden]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References