Detailed information of TA system TA025107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 3601024..3601641
• Replicon: chromosome
• Accession: NC_015061
• Organism: Rahnella sp. Y9602

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: H8NYI7
• Locus tag: RAHAQ_RS16535
• Protein ID: WP_013576617.1
• Coordinates: 3601438..3601641 (+)
• Length: 68 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: H8NYI6
• Locus tag: RAHAQ_RS16530
• Protein ID: WP_013576616.1
• Coordinates: 3601024..3601392 (+)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RAHAQ_RS16500	3597014..3597268	+	255	WP_013576610.1	type B 50S ribosomal protein L31	-
RAHAQ_RS16505	3597289..3597429	+	141	WP_013576611.1	type B 50S ribosomal protein L36	-
RAHAQ_RS16510	3597554..3598432	-	879	WP_013576612.1	metal ABC transporter substrate-binding protein	-
RAHAQ_RS16515	3598476..3599333	-	858	WP_013576613.1	metal ABC transporter permease	-
RAHAQ_RS16520	3599330..3600058	-	729	WP_173362112.1	ABC transporter ATP-binding protein	-
RAHAQ_RS16525	3600441..3600794	+	354	WP_013576615.1	hypothetical protein	-
RAHAQ_RS16530	3601024..3601392	+	369	WP_013576616.1	Hha toxicity modulator TomB	Antitoxin
RAHAQ_RS16535	3601438..3601641	+	204	WP_013576617.1	hemolysin expression modulator Hha	Toxin
RAHAQ_RS16540	3601717..3602673	-	957	WP_013576618.1	LysR family transcriptional regulator	-
RAHAQ_RS16545	3602813..3604600	+	1788	WP_013576619.1	adenine deaminase	-
RAHAQ_RS16550	3604677..3606026	+	1350	WP_013576620.1	NCS2 family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (8-64)

Antitoxin

• Biofilm formation regulator YbaJ (1-118)

Sequences

Toxin

Protein

• Length: 68 a.a.
• Molecular weight: 8114.45 Da
• Isoelectric Point: 6.9764

>T25107 WP_013576617.1 NC_015061:3601438-3601641 [Rahnella sp. Y9602]
MNKIDYLMRLRKCTTIDTLERVIEKNKYELSDDELELFYSAADHRLAELTMNKLYDKIPVSVWKFVR

Nucleotide

• Length: 204 bp

>T25107 NC_015061:3601438-3601641 [Rahnella sp. Y9602]
ATGAACAAAATCGACTATTTGATGCGTTTACGAAAATGCACCACTATCGATACACTTGAACGTGTTATTGAAAAAAATAA
GTACGAACTTTCCGACGACGAGCTGGAATTGTTTTACTCGGCAGCTGACCATCGTTTAGCGGAGCTAACGATGAACAAGT
TGTACGATAAAATCCCGGTATCAGTCTGGAAATTTGTACGCTGA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 14391.15 Da
• Isoelectric Point: 4.7281

>AT25107 WP_013576616.1 NC_015061:3601024-3601392 [Rahnella sp. Y9602]
MDEYSPKRHDIAQLRYLNEMLYDEGIATLGDSHHGWVNDPTSAVNLQLNELIEHIASFVMSFKIKYPDDNHLSDLVEEYL
DDTYTLFSNYGINDSDLRQWQKTKKRLFRMFSGDYICTLMKT

Nucleotide

• Length: 369 bp

>AT25107 NC_015061:3601024-3601392 [Rahnella sp. Y9602]
ATGGATGAGTACTCGCCTAAGCGGCACGATATCGCTCAGTTACGCTACCTGAATGAAATGCTGTATGATGAAGGGATTGC
GACACTGGGTGACAGTCATCATGGTTGGGTTAACGATCCGACTTCGGCTGTTAACTTGCAGCTCAATGAACTGATTGAGC
ACATTGCATCCTTTGTGATGAGTTTTAAAATTAAGTATCCAGACGATAACCATTTAAGTGATCTGGTTGAAGAGTATCTG
GATGATACCTACACGCTGTTCAGTAATTATGGAATTAACGATTCTGATTTACGCCAATGGCAAAAGACCAAGAAGCGGTT
ATTCAGAATGTTCTCAGGGGACTACATCTGTACCCTAATGAAGACTTGA

Structures

Toxin

• AlphaFold DB: H8NYI7

Antitoxin

• AlphaFold DB: H8NYI6