Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4225930..4226711 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I1HVL4
Locus tag NL712_RS20530 Protein ID WP_023255089.1
Coordinates 4225930..4226421 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NL712_RS20535 Protein ID WP_001271379.1
Coordinates 4226418..4226711 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS20505 (4222811) 4222811..4223641 - 831 WP_079948288.1 fimbria/pilus periplasmic chaperone -
NL712_RS20510 (4223843) 4223843..4224055 - 213 WP_001293880.1 PapB/FocB family fimbrial expression transcriptional regulator -
NL712_RS20515 (4224680) 4224680..4224823 + 144 Protein_4013 transposase -
NL712_RS20520 (4224840) 4224840..4225186 + 347 Protein_4014 Rpn family recombination-promoting nuclease/putative transposase -
NL712_RS20525 (4225467) 4225467..4225715 - 249 Protein_4015 IS481 family transposase -
NL712_RS20530 (4225930) 4225930..4226421 - 492 WP_023255089.1 GNAT family N-acetyltransferase Toxin
NL712_RS20535 (4226418) 4226418..4226711 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NL712_RS20540 (4227029) 4227029..4227251 + 223 Protein_4018 hypothetical protein -
NL712_RS20545 (4227517) 4227517..4228392 + 876 WP_000921674.1 AraC family transcriptional regulator -
NL712_RS20550 (4228389) 4228389..4228676 + 288 WP_001269916.1 transcriptional regulator RtsB -
NL712_RS20555 (4228699) 4228699..4228913 + 215 Protein_4021 hypothetical protein -
NL712_RS20560 (4228921) 4228921..4229064 + 144 Protein_4022 hypothetical protein -
NL712_RS20565 (4229176) 4229176..4229265 + 90 Protein_4023 hypothetical protein -
NL712_RS20570 (4229554) 4229554..4230459 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4215323..4229265 13942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17633.45 Da        Isoelectric Point: 7.7297

>T251063 WP_023255089.1 NZ_CP100693:c4226421-4225930 [Salmonella enterica subsp. enterica serovar London]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT251063 WP_001271379.1 NZ_CP100693:c4226711-4226418 [Salmonella enterica subsp. enterica serovar London]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I1HVL4

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References