Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4111349..4111865 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name relE Uniprot ID A0A5I6CHB9
Locus tag NL712_RS19900 Protein ID WP_000220581.1
Coordinates 4111349..4111633 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag NL712_RS19905 Protein ID WP_000212724.1
Coordinates 4111623..4111865 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS19885 (4106561) 4106561..4108213 + 1653 WP_023257400.1 alpha,alpha-phosphotrehalase -
NL712_RS19890 (4108622) 4108622..4110760 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
NL712_RS19895 (4110881) 4110881..4111345 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NL712_RS19900 (4111349) 4111349..4111633 - 285 WP_000220581.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL712_RS19905 (4111623) 4111623..4111865 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NL712_RS19910 (4111943) 4111943..4113856 - 1914 WP_001212148.1 BglG family transcription antiterminator -
NL712_RS19915 (4113873) 4113873..4114613 - 741 WP_023229489.1 KDGP aldolase family protein -
NL712_RS19920 (4114610) 4114610..4115728 - 1119 WP_023256352.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
NL712_RS19925 (4115712) 4115712..4116845 - 1134 WP_023257225.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10868.70 Da        Isoelectric Point: 10.0482

>T251062 WP_000220581.1 NZ_CP100693:c4111633-4111349 [Salmonella enterica subsp. enterica serovar London]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT251062 WP_000212724.1 NZ_CP100693:c4111865-4111623 [Salmonella enterica subsp. enterica serovar London]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I6CHB9

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References