Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4026200..4026776 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NL712_RS19510 Protein ID WP_001131963.1
Coordinates 4026489..4026776 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A5J0SGD3
Locus tag NL712_RS19505 Protein ID WP_023254955.1
Coordinates 4026200..4026502 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS19490 (4022710) 4022710..4024860 + 2151 WP_000379927.1 pyruvate/proton symporter BtsT -
NL712_RS19495 (4024955) 4024955..4025158 + 204 WP_000460616.1 YbdD/YjiX family protein -
NL712_RS19500 (4025169) 4025169..4026125 + 957 WP_000187838.1 GTPase -
NL712_RS19505 (4026200) 4026200..4026502 - 303 WP_023254955.1 BrnA antitoxin family protein Antitoxin
NL712_RS19510 (4026489) 4026489..4026776 - 288 WP_001131963.1 BrnT family toxin Toxin
NL712_RS19515 (4027045) 4027045..4027959 - 915 WP_000290515.1 restriction endonuclease -
NL712_RS19520 (4028157) 4028157..4031666 + 3510 WP_023256869.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(39-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T251061 WP_001131963.1 NZ_CP100693:c4026776-4026489 [Salmonella enterica subsp. enterica serovar London]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11346.01 Da        Isoelectric Point: 10.1339

>AT251061 WP_023254955.1 NZ_CP100693:c4026502-4026200 [Salmonella enterica subsp. enterica serovar London]
MSMVKHKRGNACALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSGAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A5J0SGD3

References