Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3410762..3411382 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL712_RS16665 Protein ID WP_001280991.1
Coordinates 3411164..3411382 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL712_RS16660 Protein ID WP_000344807.1
Coordinates 3410762..3411136 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS16650 (3405901) 3405901..3407094 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL712_RS16655 (3407117) 3407117..3410266 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL712_RS16660 (3410762) 3410762..3411136 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL712_RS16665 (3411164) 3411164..3411382 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL712_RS16670 (3411561) 3411561..3412112 + 552 WP_023243161.1 maltose O-acetyltransferase -
NL712_RS16675 (3412230) 3412230..3412700 + 471 WP_000136183.1 YlaC family protein -
NL712_RS16680 (3412756) 3412756..3412896 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL712_RS16685 (3412902) 3412902..3413162 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL712_RS16690 (3413387) 3413387..3414937 + 1551 WP_000213145.1 EAL domain-containing protein -
NL712_RS16700 (3415168) 3415168..3415557 + 390 WP_000961285.1 MGMT family protein -
NL712_RS16705 (3415590) 3415590..3416159 - 570 WP_000779801.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251058 WP_001280991.1 NZ_CP100693:3411164-3411382 [Salmonella enterica subsp. enterica serovar London]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251058 WP_000344807.1 NZ_CP100693:3410762-3411136 [Salmonella enterica subsp. enterica serovar London]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References