Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 852994..853619 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NL712_RS04120 Protein ID WP_000911337.1
Coordinates 853221..853619 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NL712_RS04115 Protein ID WP_000557549.1
Coordinates 852994..853221 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS04085 (848059) 848059..849157 + 1099 WP_010989230.1 peptide chain release factor 2 -
NL712_RS04090 (849167) 849167..850684 + 1518 WP_000003339.1 lysine--tRNA ligase -
NL712_RS04095 (850760) 850760..851305 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NL712_RS04100 (851570) 851570..852328 + 759 WP_000244328.1 amidase activator ActS -
NL712_RS04110 (852574) 852574..852771 - 198 WP_023255488.1 hypothetical protein -
NL712_RS04115 (852994) 852994..853221 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL712_RS04120 (853221) 853221..853619 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NL712_RS04125 (854425) 854425..854961 + 537 WP_001038500.1 STM3031 family outer membrane protein -
NL712_RS04130 (855008) 855008..855640 + 633 WP_000835264.1 YfdX family protein -
NL712_RS04135 (856359) 856359..856943 + 585 WP_001244638.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 852994..862811 9817


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T251052 WP_000911337.1 NZ_CP100693:853221-853619 [Salmonella enterica subsp. enterica serovar London]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT251052 WP_000557549.1 NZ_CP100693:852994-853221 [Salmonella enterica subsp. enterica serovar London]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References