Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843235..843895 Replicon chromosome
Accession NZ_CP100693
Organism Salmonella enterica subsp. enterica serovar London strain R18.1595

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I0Q7R2
Locus tag NL712_RS04060 Protein ID WP_023255487.1
Coordinates 843482..843895 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A3U5J6N8
Locus tag NL712_RS04055 Protein ID WP_058805755.1
Coordinates 843235..843501 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL712_RS04035 (839164) 839164..840597 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NL712_RS04040 (840755) 840755..841066 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NL712_RS04045 (841230) 841230..841889 + 660 WP_000250289.1 hemolysin III family protein -
NL712_RS04050 (842005) 842005..842985 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
NL712_RS04055 (843235) 843235..843501 + 267 WP_058805755.1 FAD assembly factor SdhE Antitoxin
NL712_RS04060 (843482) 843482..843895 + 414 WP_023255487.1 protein YgfX Toxin
NL712_RS04065 (843948) 843948..844469 - 522 WP_001055885.1 flavodoxin FldB -
NL712_RS04070 (844582) 844582..845478 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL712_RS04075 (845502) 845502..846215 + 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL712_RS04080 (846221) 846221..847954 + 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16197.18 Da        Isoelectric Point: 10.7537

>T251051 WP_023255487.1 NZ_CP100693:843482-843895 [Salmonella enterica subsp. enterica serovar London]
VILWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10608.09 Da        Isoelectric Point: 5.5844

>AT251051 WP_058805755.1 NZ_CP100693:843235-843501 [Salmonella enterica subsp. enterica serovar London]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERDPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I0Q7R2

Antitoxin

Source ID Structure
AlphaFold DB A0A3U5J6N8

References