Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3605510..3606130 Replicon chromosome
Accession NZ_CP100691
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL690_RS17785 Protein ID WP_001280991.1
Coordinates 3605912..3606130 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL690_RS17780 Protein ID WP_000344807.1
Coordinates 3605510..3605884 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL690_RS17770 (3600649) 3600649..3601842 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL690_RS17775 (3601865) 3601865..3605014 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL690_RS17780 (3605510) 3605510..3605884 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL690_RS17785 (3605912) 3605912..3606130 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL690_RS17790 (3606309) 3606309..3606860 + 552 WP_001278792.1 maltose O-acetyltransferase -
NL690_RS17795 (3606977) 3606977..3607447 + 471 WP_000136181.1 YlaC family protein -
NL690_RS17800 (3607503) 3607503..3607643 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL690_RS17805 (3607649) 3607649..3607909 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL690_RS17810 (3608134) 3608134..3609684 + 1551 WP_000213139.1 EAL domain-containing protein -
NL690_RS17820 (3609915) 3609915..3610304 + 390 WP_000961285.1 MGMT family protein -
NL690_RS17825 (3610337) 3610337..3610906 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251044 WP_001280991.1 NZ_CP100691:3605912-3606130 [Salmonella enterica subsp. enterica serovar Typhimurium]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251044 WP_000344807.1 NZ_CP100691:3605510-3605884 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References