Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 917965..918625 Replicon chromosome
Accession NZ_CP100691
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag NL690_RS04460 Protein ID WP_000244756.1
Coordinates 918212..918625 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag NL690_RS04455 Protein ID WP_000351186.1
Coordinates 917965..918231 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL690_RS04435 (913893) 913893..915326 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
NL690_RS04440 (915485) 915485..915796 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
NL690_RS04445 (915960) 915960..916619 + 660 WP_000250289.1 hemolysin III family protein -
NL690_RS04450 (916735) 916735..917715 - 981 WP_099949610.1 tRNA-modifying protein YgfZ -
NL690_RS04455 (917965) 917965..918231 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
NL690_RS04460 (918212) 918212..918625 + 414 WP_000244756.1 protein YgfX Toxin
NL690_RS04465 (918678) 918678..919199 - 522 WP_001055885.1 flavodoxin FldB -
NL690_RS04470 (919312) 919312..920208 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
NL690_RS04475 (920232) 920232..920945 + 714 WP_000745625.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NL690_RS04480 (920951) 920951..922684 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251036 WP_000244756.1 NZ_CP100691:918212-918625 [Salmonella enterica subsp. enterica serovar Typhimurium]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251036 WP_000351186.1 NZ_CP100691:917965-918231 [Salmonella enterica subsp. enterica serovar Typhimurium]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References