Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 290410..291170 Replicon chromosome
Accession NZ_CP100691
Organism Salmonella enterica subsp. enterica serovar Typhimurium strain R17.3867

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag NL690_RS01405 Protein ID WP_000533909.1
Coordinates 290685..291170 (+) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NL690_RS01400 Protein ID WP_000965886.1
Coordinates 290410..290697 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL690_RS01375 (285705) 285705..286007 + 303 WP_000605590.1 YsaB family lipoprotein -
NL690_RS01380 (286146) 286146..287057 + 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -
NL690_RS01385 (287067) 287067..289136 + 2070 WP_001291736.1 glycine--tRNA ligase subunit beta -
NL690_RS01390 (289318) 289318..289593 + 276 Protein_276 IS3 family transposase -
NL690_RS01395 (289765) 289765..290232 + 468 WP_000702452.1 GNAT family N-acetyltransferase -
NL690_RS01400 (290410) 290410..290697 + 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NL690_RS01405 (290685) 290685..291170 + 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
NL690_RS01410 (291542) 291542..292081 - 540 WP_000047149.1 copper-binding periplasmic metallochaperone CueP -
NL690_RS01415 (292255) 292255..292467 - 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NL690_RS01420 (292756) 292756..293046 - 291 WP_000455790.1 HTH-type transcriptional regulator -
NL690_RS01425 (293485) 293485..294195 + 711 WP_000190524.1 DUF3053 domain-containing protein -
NL690_RS01430 (294245) 294245..295219 - 975 WP_000804674.1 glyoxylate/hydroxypyruvate reductase GhrB -
NL690_RS01435 (295438) 295438..296100 - 663 WP_000747548.1 OmpA family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T251034 WP_000533909.1 NZ_CP100691:290685-291170 [Salmonella enterica subsp. enterica serovar Typhimurium]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT251034 WP_000965886.1 NZ_CP100691:290410-290697 [Salmonella enterica subsp. enterica serovar Typhimurium]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References