Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 83577..85200 Replicon plasmid pR18.0287_259k
Accession NZ_CP100690
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag FGU70_RS23335 Protein ID WP_000088046.1
Coordinates 83875..85200 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag FGU70_RS23330 Protein ID WP_024136327.1
Coordinates 83577..83870 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU70_RS23305 (79449) 79449..80690 + 1242 WP_001053338.1 VWA domain-containing protein -
FGU70_RS23310 (81253) 81253..81534 - 282 WP_254520351.1 hypothetical protein -
FGU70_RS23315 (81584) 81584..81775 - 192 WP_000398480.1 hypothetical protein -
FGU70_RS23320 (81867) 81867..82208 - 342 WP_001151575.1 hypothetical protein -
FGU70_RS23325 (82581) 82581..82973 + 393 WP_000341066.1 hypothetical protein -
FGU70_RS23330 (83577) 83577..83870 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
FGU70_RS23335 (83875) 83875..85200 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
FGU70_RS23340 (85261) 85261..85467 + 207 WP_000134171.1 hypothetical protein -
FGU70_RS23345 (85569) 85569..85979 + 411 WP_000985911.1 hypothetical protein -
FGU70_RS23350 (85992) 85992..86807 + 816 WP_053276223.1 HNH endonuclease signature motif containing protein -
FGU70_RS23355 (87061) 87061..87486 + 426 WP_001043843.1 hypothetical protein -
FGU70_RS23360 (88035) 88035..88343 + 309 WP_001224687.1 hypothetical protein -
FGU70_RS23365 (88359) 88359..89216 + 858 WP_000784387.1 HNH endonuclease signature motif containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid aph(3')-Ia / sul3 / ant(3'')-Ia / floR / aadA2 / lnu(F) / mph(A) / tet(A) / aph(6)-Id / aph(3'')-Ib / aac(3)-IId / dfrA12 / blaCMY-2 - 1..258970 258970


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T251033 WP_000088046.1 NZ_CP100690:83875-85200 [Salmonella enterica subsp. enterica serovar Newport]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT251033 WP_024136327.1 NZ_CP100690:83577-83870 [Salmonella enterica subsp. enterica serovar Newport]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References