Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4236969..4237750 Replicon chromosome
Accession NZ_CP100689
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A0R9NZI3
Locus tag FGU70_RS20560 Protein ID WP_000625912.1
Coordinates 4236969..4237460 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID M7RNV8
Locus tag FGU70_RS20565 Protein ID WP_001110450.1
Coordinates 4237457..4237750 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU70_RS20535 (4233851) 4233851..4234681 - 831 WP_001180236.1 fimbria/pilus periplasmic chaperone -
FGU70_RS20540 (4234925) 4234925..4235095 - 171 Protein_4014 adhesin biosynthesis transcription regulatory family protein -
FGU70_RS20545 (4235719) 4235719..4235862 + 144 Protein_4015 transposase -
FGU70_RS20550 (4235879) 4235879..4236225 + 347 Protein_4016 Rpn family recombination-promoting nuclease/putative transposase -
FGU70_RS20555 (4236506) 4236506..4236754 - 249 Protein_4017 IS481 family transposase -
FGU70_RS20560 (4236969) 4236969..4237460 - 492 WP_000625912.1 GNAT family N-acetyltransferase Toxin
FGU70_RS20565 (4237457) 4237457..4237750 - 294 WP_001110450.1 DUF1778 domain-containing protein Antitoxin
FGU70_RS20570 (4238067) 4238067..4238289 + 223 Protein_4020 hypothetical protein -
FGU70_RS20575 (4238553) 4238553..4239428 + 876 WP_000921676.1 AraC family transcriptional regulator -
FGU70_RS20580 (4239425) 4239425..4239712 + 288 WP_001269916.1 transcriptional regulator RtsB -
FGU70_RS20585 (4239705) 4239705..4239887 - 183 WP_001670702.1 ATP-binding cassette domain-containing protein -
FGU70_RS20590 (4239907) 4239907..4240006 + 100 Protein_4024 hypothetical protein -
FGU70_RS20595 (4240123) 4240123..4240257 + 135 Protein_4025 hypothetical protein -
FGU70_RS20600 (4240552) 4240552..4241457 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4230057..4239712 9655


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17606.43 Da        Isoelectric Point: 7.7297

>T251030 WP_000625912.1 NZ_CP100689:c4237460-4236969 [Salmonella enterica subsp. enterica serovar Newport]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSSVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10949.56 Da        Isoelectric Point: 8.6141

>AT251030 WP_001110450.1 NZ_CP100689:c4237750-4237457 [Salmonella enterica subsp. enterica serovar Newport]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0R9NZI3

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9PGG6

References