Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3428818..3429438 Replicon chromosome
Accession NZ_CP100689
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag FGU70_RS16740 Protein ID WP_001280991.1
Coordinates 3429220..3429438 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag FGU70_RS16735 Protein ID WP_000344807.1
Coordinates 3428818..3429192 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU70_RS16725 (3423957) 3423957..3425150 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FGU70_RS16730 (3425173) 3425173..3428322 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
FGU70_RS16735 (3428818) 3428818..3429192 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
FGU70_RS16740 (3429220) 3429220..3429438 + 219 WP_001280991.1 HHA domain-containing protein Toxin
FGU70_RS16745 (3429617) 3429617..3430168 + 552 WP_001278794.1 maltose O-acetyltransferase -
FGU70_RS16750 (3430285) 3430285..3430755 + 471 WP_000136181.1 YlaC family protein -
FGU70_RS16755 (3430811) 3430811..3430951 - 141 WP_001197750.1 type B 50S ribosomal protein L36 -
FGU70_RS16760 (3430957) 3430957..3431217 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
FGU70_RS16765 (3431442) 3431442..3432992 + 1551 WP_000213146.1 EAL domain-containing protein -
FGU70_RS16775 (3433223) 3433223..3433612 + 390 WP_000961287.1 MGMT family protein -
FGU70_RS16780 (3433645) 3433645..3434214 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251026 WP_001280991.1 NZ_CP100689:3429220-3429438 [Salmonella enterica subsp. enterica serovar Newport]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251026 WP_000344807.1 NZ_CP100689:3428818-3429192 [Salmonella enterica subsp. enterica serovar Newport]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References