Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1013011..1013825 Replicon chromosome
Accession NZ_CP100689
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag FGU70_RS04850 Protein ID WP_000971655.1
Coordinates 1013011..1013538 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag FGU70_RS04855 Protein ID WP_000855694.1
Coordinates 1013535..1013825 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU70_RS04810 (1008132) 1008132..1008302 + 171 WP_000069461.1 hypothetical protein -
FGU70_RS04815 (1008299) 1008299..1008916 - 618 WP_000092527.1 Fic family protein -
FGU70_RS04820 (1009293) 1009293..1009691 + 399 Protein_944 cytoplasmic protein -
FGU70_RS04825 (1009882) 1009882..1010121 + 240 Protein_945 hypothetical protein -
FGU70_RS04830 (1010278) 1010278..1010946 + 669 WP_000445914.1 hypothetical protein -
FGU70_RS04835 (1010973) 1010973..1011467 + 495 WP_000424948.1 hypothetical protein -
FGU70_RS04840 (1011639) 1011639..1012295 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
FGU70_RS04845 (1012528) 1012528..1012938 + 411 Protein_949 transposase -
FGU70_RS04850 (1013011) 1013011..1013538 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
FGU70_RS04855 (1013535) 1013535..1013825 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
FGU70_RS04860 (1014095) 1014095..1014273 - 179 Protein_952 IS3 family transposase -
FGU70_RS04865 (1014514) 1014514..1014840 + 327 WP_000393302.1 hypothetical protein -
FGU70_RS04870 (1015113) 1015113..1015460 - 348 WP_001669174.1 DUF1493 family protein -
FGU70_RS04875 (1015445) 1015445..1015894 - 450 WP_000381610.1 membrane protein -
FGU70_RS04880 (1016326) 1016326..1016769 - 444 WP_000715099.1 SPI-1 type III secretion system invasion lipoprotein InvH -
FGU70_RS04885 (1017225) 1017225..1017875 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island tet(B) invH / invF / invG / invE / invA / invB 977262..1023188 45926
- flank IS/Tn - - 1012714..1012938 224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T251021 WP_000971655.1 NZ_CP100689:c1013538-1013011 [Salmonella enterica subsp. enterica serovar Newport]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT251021 WP_000855694.1 NZ_CP100689:c1013825-1013535 [Salmonella enterica subsp. enterica serovar Newport]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References