Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 834881..835506 Replicon chromosome
Accession NZ_CP100689
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag FGU70_RS04025 Protein ID WP_000911337.1
Coordinates 835108..835506 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID C0PXM4
Locus tag FGU70_RS04020 Protein ID WP_000557545.1
Coordinates 834881..835108 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU70_RS03990 (829926) 829926..831443 + 1518 WP_000003339.1 lysine--tRNA ligase -
FGU70_RS03995 (831519) 831519..832064 - 546 WP_000133986.1 isopentenyl-diphosphate Delta-isomerase -
FGU70_RS04000 (832329) 832329..833087 + 759 WP_000244328.1 amidase activator ActS -
FGU70_RS04010 (833372) 833372..834178 - 807 WP_010989071.1 DUF1460 domain-containing protein -
FGU70_RS04015 (834453) 834453..834704 - 252 WP_001540858.1 hypothetical protein -
FGU70_RS04020 (834881) 834881..835108 + 228 WP_000557545.1 toxin-antitoxin system antitoxin VapB Antitoxin
FGU70_RS04025 (835108) 835108..835506 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
FGU70_RS04030 (836313) 836313..836849 + 537 WP_001038502.1 STM3031 family outer membrane protein -
FGU70_RS04035 (836896) 836896..837528 + 633 WP_000835265.1 YfdX family protein -
FGU70_RS04040 (838247) 838247..838828 + 582 WP_001244652.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 834453..843300 8847


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T251020 WP_000911337.1 NZ_CP100689:835108-835506 [Salmonella enterica subsp. enterica serovar Newport]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8500.48 Da        Isoelectric Point: 5.0053

>AT251020 WP_000557545.1 NZ_CP100689:834881-835108 [Salmonella enterica subsp. enterica serovar Newport]
MHTTLFFSNRTQAVRLPKSISFPDDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0R9MGW6

References