Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 823994..824654 Replicon chromosome
Accession NZ_CP100689
Organism Salmonella enterica subsp. enterica serovar Newport strain R18.0287

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag FGU70_RS03960 Protein ID WP_000244756.1
Coordinates 824241..824654 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag FGU70_RS03955 Protein ID WP_000351186.1
Coordinates 823994..824260 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FGU70_RS03935 (819926) 819926..821359 - 1434 WP_001230141.1 6-phospho-beta-glucosidase BglA -
FGU70_RS03940 (821514) 821514..821828 + 315 WP_001182980.1 N(4)-acetylcytidine aminohydrolase -
FGU70_RS03945 (821989) 821989..822648 + 660 WP_000250289.1 hemolysin III family protein -
FGU70_RS03950 (822764) 822764..823744 - 981 WP_000874176.1 tRNA-modifying protein YgfZ -
FGU70_RS03955 (823994) 823994..824260 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
FGU70_RS03960 (824241) 824241..824654 + 414 WP_000244756.1 protein YgfX Toxin
FGU70_RS03965 (824707) 824707..825228 - 522 WP_001055885.1 flavodoxin FldB -
FGU70_RS03970 (825341) 825341..826237 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
FGU70_RS03975 (826261) 826261..826974 + 714 WP_000745621.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
FGU70_RS03980 (826980) 826980..828713 + 1734 WP_000813394.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T251019 WP_000244756.1 NZ_CP100689:824241-824654 [Salmonella enterica subsp. enterica serovar Newport]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT251019 WP_000351186.1 NZ_CP100689:823994-824260 [Salmonella enterica subsp. enterica serovar Newport]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References