Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3305171..3305791 Replicon chromosome
Accession NZ_CP100685
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain R18.1297

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag FC640_RS15950 Protein ID WP_001280991.1
Coordinates 3305573..3305791 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag FC640_RS15945 Protein ID WP_000344807.1
Coordinates 3305171..3305545 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC640_RS15935 (3300310) 3300310..3301503 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FC640_RS15940 (3301526) 3301526..3304675 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
FC640_RS15945 (3305171) 3305171..3305545 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
FC640_RS15950 (3305573) 3305573..3305791 + 219 WP_001280991.1 HHA domain-containing protein Toxin
FC640_RS15955 (3305970) 3305970..3306521 + 552 WP_001278793.1 maltose O-acetyltransferase -
FC640_RS15960 (3306637) 3306637..3307107 + 471 WP_000136183.1 YlaC family protein -
FC640_RS15965 (3307163) 3307163..3307303 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
FC640_RS15970 (3307309) 3307309..3307569 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
FC640_RS15975 (3307794) 3307794..3309344 + 1551 WP_000213138.1 EAL domain-containing protein -
FC640_RS15985 (3309575) 3309575..3309964 + 390 WP_000961285.1 MGMT family protein -
FC640_RS15990 (3309997) 3309997..3310566 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T251010 WP_001280991.1 NZ_CP100685:3305573-3305791 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT251010 WP_000344807.1 NZ_CP100685:3305171-3305545 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References