Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 213392..214152 | Replicon | chromosome |
| Accession | NZ_CP100685 | ||
| Organism | Salmonella enterica subsp. enterica serovar Goldcoast strain R18.1297 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | FC640_RS01000 | Protein ID | WP_000533909.1 |
| Coordinates | 213667..214152 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | Q8Z2B2 |
| Locus tag | FC640_RS00995 | Protein ID | WP_000965889.1 |
| Coordinates | 213392..213679 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| FC640_RS00975 (208738) | 208738..210066 | - | 1329 | WP_000200570.1 | MFS transporter | - |
| FC640_RS00980 (210254) | 210254..211414 | - | 1161 | WP_000107288.1 | mandelate racemase/muconate lactonizing enzyme family protein | - |
| FC640_RS00985 (211520) | 211520..212419 | + | 900 | WP_000462482.1 | LysR family transcriptional regulator | - |
| FC640_RS00990 (212556) | 212556..213209 | - | 654 | WP_001139163.1 | LysE family translocator | - |
| FC640_RS00995 (213392) | 213392..213679 | + | 288 | WP_000965889.1 | DUF1778 domain-containing protein | Antitoxin |
| FC640_RS01000 (213667) | 213667..214152 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| FC640_RS01005 (214524) | 214524..215063 | - | 540 | WP_000047148.1 | copper-binding periplasmic metallochaperone CueP | - |
| FC640_RS01010 (215237) | 215237..215449 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| FC640_RS01015 (215737) | 215737..216027 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| FC640_RS01020 (216466) | 216466..217176 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| FC640_RS01025 (217226) | 217226..218200 | - | 975 | WP_000804681.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| FC640_RS01030 (218419) | 218419..219081 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T251002 WP_000533909.1 NZ_CP100685:213667-214152 [Salmonella enterica subsp. enterica serovar Goldcoast]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10964.59 Da Isoelectric Point: 4.6811
>AT251002 WP_000965889.1 NZ_CP100685:213392-213679 [Salmonella enterica subsp. enterica serovar Goldcoast]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACRAAENVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A752RW74 |