Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 3998142..3998658 Replicon chromosome
Accession NZ_CP100682
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain R18.0450

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag FC623_RS19130 Protein ID WP_133323120.1
Coordinates 3998142..3998426 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag FC623_RS19135 Protein ID WP_000212724.1
Coordinates 3998416..3998658 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC623_RS19115 (3993354) 3993354..3995006 + 1653 WP_023137597.1 alpha,alpha-phosphotrehalase -
FC623_RS19120 (3995415) 3995415..3997553 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
FC623_RS19125 (3997674) 3997674..3998138 + 465 WP_133323118.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
FC623_RS19130 (3998142) 3998142..3998426 - 285 WP_133323120.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
FC623_RS19135 (3998416) 3998416..3998658 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
FC623_RS19140 (3998736) 3998736..4000649 - 1914 WP_001212140.1 BglG family transcription antiterminator -
FC623_RS19145 (4000666) 4000666..4001406 - 741 WP_023229489.1 KDGP aldolase family protein -
FC623_RS19150 (4001403) 4001403..4002521 - 1119 WP_133323122.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
FC623_RS19155 (4002505) 4002505..4003638 - 1134 WP_133323124.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10926.73 Da        Isoelectric Point: 9.8739

>T250998 WP_133323120.1 NZ_CP100682:c3998426-3998142 [Salmonella enterica subsp. enterica serovar Goldcoast]
MTYELEFDPRALKEWHKLDDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDEVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT250998 WP_000212724.1 NZ_CP100682:c3998658-3998416 [Salmonella enterica subsp. enterica serovar Goldcoast]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References