Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3305164..3305784 Replicon chromosome
Accession NZ_CP100682
Organism Salmonella enterica subsp. enterica serovar Goldcoast strain R18.0450

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag FC623_RS15955 Protein ID WP_001280991.1
Coordinates 3305566..3305784 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag FC623_RS15950 Protein ID WP_000344807.1
Coordinates 3305164..3305538 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FC623_RS15940 (3300303) 3300303..3301496 + 1194 WP_126524221.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
FC623_RS15945 (3301519) 3301519..3304668 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
FC623_RS15950 (3305164) 3305164..3305538 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
FC623_RS15955 (3305566) 3305566..3305784 + 219 WP_001280991.1 HHA domain-containing protein Toxin
FC623_RS15960 (3305963) 3305963..3306514 + 552 WP_001278793.1 maltose O-acetyltransferase -
FC623_RS15965 (3306630) 3306630..3307100 + 471 WP_000136183.1 YlaC family protein -
FC623_RS15970 (3307156) 3307156..3307296 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
FC623_RS15975 (3307302) 3307302..3307562 - 261 WP_115276046.1 type B 50S ribosomal protein L31 -
FC623_RS15980 (3307787) 3307787..3309337 + 1551 WP_000213138.1 EAL domain-containing protein -
FC623_RS15990 (3309568) 3309568..3309957 + 390 WP_000961285.1 MGMT family protein -
FC623_RS15995 (3309990) 3309990..3310559 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T250995 WP_001280991.1 NZ_CP100682:3305566-3305784 [Salmonella enterica subsp. enterica serovar Goldcoast]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT250995 WP_000344807.1 NZ_CP100682:3305164-3305538 [Salmonella enterica subsp. enterica serovar Goldcoast]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References