Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4227813..4228594 Replicon chromosome
Accession NZ_CP100678
Organism Salmonella enterica subsp. enterica serovar Anatum strain R17.0809

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5I5SY00
Locus tag NL708_RS20555 Protein ID WP_000626104.1
Coordinates 4227813..4228304 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NL708_RS20560 Protein ID WP_001110452.1
Coordinates 4228301..4228594 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL708_RS20530 (4222953) 4222953..4225391 - 2439 WP_001014138.1 F4 (K88) fimbrial usher FaeD -
NL708_RS20535 (4225401) 4225401..4225940 - 540 WP_000721295.1 type 1 fimbrial protein -
NL708_RS20540 (4225975) 4225975..4226259 - 285 WP_205903706.1 PapB/FocB family fimbrial expression transcriptional regulator -
NL708_RS20545 (4226848) 4226848..4227075 + 228 WP_001519955.1 hypothetical protein -
NL708_RS20550 (4227350) 4227350..4227598 - 249 Protein_4022 IS481 family transposase -
NL708_RS20555 (4227813) 4227813..4228304 - 492 WP_000626104.1 GNAT family N-acetyltransferase Toxin
NL708_RS20560 (4228301) 4228301..4228594 - 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NL708_RS20565 (4228911) 4228911..4229132 + 222 WP_021001044.1 hypothetical protein -
NL708_RS20570 (4229398) 4229398..4230273 + 876 WP_000921676.1 AraC family transcriptional regulator -
NL708_RS20575 (4230270) 4230270..4230557 + 288 WP_001269916.1 transcriptional regulator RtsB -
NL708_RS20580 (4230580) 4230580..4230795 + 216 WP_001595136.1 hypothetical protein -
NL708_RS20585 (4230803) 4230803..4231072 + 270 WP_010989096.1 hypothetical protein -
NL708_RS20590 (4231366) 4231366..4232271 - 906 WP_001268200.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4216177..4231072 14895


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17631.42 Da        Isoelectric Point: 7.7297

>T250980 WP_000626104.1 NZ_CP100678:c4228304-4227813 [Salmonella enterica subsp. enterica serovar Anatum]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T250980 NZ_CP100678:c4228304-4227813 [Salmonella enterica subsp. enterica serovar Anatum]
ATGATCTCCACCCCTGAGCCGCTTCATGCCGGACATATTCTTACTCCGTTTTGCTGCGGTGTGGATTCTATAGATAACTG
GCTGAAACAGCGGGCGATGAAAAATCAGACCACTGGCGCGTCCCGTACCTTTGTGTGTTGTGGCAGCGATTCGAACGTAC
TGGCCTATTACTCGCTGGCGTCCAGCGCGGTCACGACGAATACCTCCCCCGGTCGCTTTCGTCGCAATATGCCTGACCCG
ATTCCGGTTGTGGTATTGGGGCGTCTGGCGGTGGATAAATCGCTTCATGGGCAGGGCGTTGGTCGGGCGCTGGTACGCGA
CGCAGGGCTGCGGGTTATTCAAGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCGC
GGGAATTTTACCAGCGGGTGGGGTTTGTACCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGGGGGATTTGGTG
GAGAGTGTTTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT250980 WP_001110452.1 NZ_CP100678:c4228594-4228301 [Salmonella enterica subsp. enterica serovar Anatum]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT250980 NZ_CP100678:c4228594-4228301 [Salmonella enterica subsp. enterica serovar Anatum]
ATGCCAGCCGCAAACAGTATGGCGATGAAACGTGAAACTCTGAACCTGCGTATCAAACCCGCCGAGCGCGATCTTATTGA
TCGAGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAAGCTGCCCGTGCTGCCGCAGAAGAAGCGCTTA
TCGAACAACGCATCATTATGGCCGATCCAGAGGCTTATCAGGAATTTCTCGTTCGTTTGGATCAAACACCTTCACCTAAT
GCCGCACTGCGTAAAACCATGCAGACCCCTGCGCCGTGGGAGCAGGAAAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5SY00

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References