Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4011216..4011792 Replicon chromosome
Accession NZ_CP100678
Organism Salmonella enterica subsp. enterica serovar Anatum strain R17.0809

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NL708_RS19450 Protein ID WP_001131963.1
Coordinates 4011505..4011792 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A6C6ZAR7
Locus tag NL708_RS19445 Protein ID WP_000063143.1
Coordinates 4011216..4011518 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL708_RS19430 (4007726) 4007726..4009876 + 2151 WP_023244016.1 pyruvate/proton symporter BtsT -
NL708_RS19435 (4009971) 4009971..4010174 + 204 WP_000460616.1 YbdD/YjiX family protein -
NL708_RS19440 (4010185) 4010185..4011141 + 957 WP_000612222.1 GTPase -
NL708_RS19445 (4011216) 4011216..4011518 - 303 WP_000063143.1 BrnA antitoxin family protein Antitoxin
NL708_RS19450 (4011505) 4011505..4011792 - 288 WP_001131963.1 BrnT family toxin Toxin
NL708_RS19455 (4012061) 4012061..4012975 - 915 WP_023244015.1 restriction endonuclease -
NL708_RS19460 (4013173) 4013173..4016682 + 3510 WP_023244014.1 type I restriction-modification system endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(40-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T250978 WP_001131963.1 NZ_CP100678:c4011792-4011505 [Salmonella enterica subsp. enterica serovar Anatum]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11402.01 Da        Isoelectric Point: 10.1293

>AT250978 WP_000063143.1 NZ_CP100678:c4011518-4011216 [Salmonella enterica subsp. enterica serovar Anatum]
MSMVKHKRGNASALSAQHEAELKALVKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
AlphaFold DB A0A6C6ZAR7

References