Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3408083..3408703 Replicon chromosome
Accession NZ_CP100678
Organism Salmonella enterica subsp. enterica serovar Anatum strain R17.0809

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL708_RS16675 Protein ID WP_001280991.1
Coordinates 3408485..3408703 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL708_RS16670 Protein ID WP_000344807.1
Coordinates 3408083..3408457 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL708_RS16660 (3403222) 3403222..3404415 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NL708_RS16665 (3404438) 3404438..3407587 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL708_RS16670 (3408083) 3408083..3408457 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL708_RS16675 (3408485) 3408485..3408703 + 219 WP_001280991.1 HHA domain-containing protein Toxin
NL708_RS16680 (3408882) 3408882..3409433 + 552 WP_023243161.1 maltose O-acetyltransferase -
NL708_RS16685 (3409549) 3409549..3410019 + 471 WP_000136183.1 YlaC family protein -
NL708_RS16690 (3410075) 3410075..3410215 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL708_RS16695 (3410221) 3410221..3410481 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL708_RS16700 (3410706) 3410706..3412256 + 1551 WP_023243162.1 EAL domain-containing protein -
NL708_RS16710 (3412487) 3412487..3412876 + 390 WP_000961285.1 MGMT family protein -
NL708_RS16715 (3412909) 3412909..3413478 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T250977 WP_001280991.1 NZ_CP100678:3408485-3408703 [Salmonella enterica subsp. enterica serovar Anatum]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT250977 WP_000344807.1 NZ_CP100678:3408083-3408457 [Salmonella enterica subsp. enterica serovar Anatum]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References