250975

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2293866..2294388 Replicon chromosome
Accession NZ_CP100678
Organism Salmonella enterica subsp. enterica serovar Anatum strain R17.0809

Toxin (Protein)


Gene name stbE Uniprot ID A0A5U0LRG3
Locus tag NL708_RS11025 Protein ID WP_023243932.1
Coordinates 2294104..2294388 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL708_RS11020 Protein ID WP_000885424.1
Coordinates 2293866..2294114 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL708_RS10990 (2289979) 2289979..2290535 + 557 Protein_2148 hypothetical protein -
NL708_RS10995 (2290813) 2290813..2291094 + 282 WP_001580000.1 hypothetical protein -
NL708_RS11000 (2291466) 2291466..2292062 + 597 Protein_2150 helix-turn-helix domain-containing protein -
NL708_RS11005 (2292118) 2292118..2293026 - 909 WP_077909464.1 hypothetical protein -
NL708_RS11010 (2293177) 2293177..2293509 - 333 WP_023244369.1 DUF1493 family protein -
NL708_RS11015 (2293499) 2293499..2293714 - 216 WP_000206207.1 hypothetical protein -
NL708_RS11020 (2293866) 2293866..2294114 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL708_RS11025 (2294104) 2294104..2294388 + 285 WP_023243932.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL708_RS11030 (2294559) 2294559..2294944 + 386 Protein_2156 RidA family protein -
NL708_RS11035 (2294996) 2294996..2296075 - 1080 WP_023244370.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL708_RS11040 (2296268) 2296268..2296756 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
NL708_RS11045 (2296801) 2296801..2298309 + 1509 WP_110962170.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2290813..2301166 10353


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11057.82 Da        Isoelectric Point: 10.6500

>T250975 WP_023243932.1 NZ_CP100678:2294104-2294388 [Salmonella enterica subsp. enterica serovar Anatum]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAIYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT250975 WP_000885424.1 NZ_CP100678:2293866-2294114 [Salmonella enterica subsp. enterica serovar Anatum]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5U0LRG3

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References