Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1829529..1830119 Replicon chromosome
Accession NZ_CP100678
Organism Salmonella enterica subsp. enterica serovar Anatum strain R17.0809

Toxin (Protein)


Gene name pemK Uniprot ID A0A5Z3IR43
Locus tag NL708_RS08645 Protein ID WP_023243734.1
Coordinates 1829787..1830119 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A618JW87
Locus tag NL708_RS08640 Protein ID WP_023243733.1
Coordinates 1829529..1829786 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL708_RS08625 (1826191) 1826191..1828146 - 1956 WP_024149369.1 hypothetical protein -
NL708_RS08630 (1828505) 1828505..1828978 + 474 WP_023244266.1 hypothetical protein -
NL708_RS08635 (1828975) 1828975..1829181 + 207 WP_023243732.1 helix-turn-helix transcriptional regulator -
NL708_RS08640 (1829529) 1829529..1829786 + 258 WP_023243733.1 MazE family transcriptional regulator Antitoxin
NL708_RS08645 (1829787) 1829787..1830119 + 333 WP_023243734.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NL708_RS08650 (1830954) 1830954..1831838 + 885 WP_031609821.1 integrase domain-containing protein -
NL708_RS08655 (1832783) 1832783..1834045 - 1263 WP_023244267.1 integrase arm-type DNA-binding domain-containing protein -
NL708_RS08665 (1834704) 1834704..1835009 - 306 Protein_1692 Arm DNA-binding domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11779.65 Da        Isoelectric Point: 10.5834

>T250970 WP_023243734.1 NZ_CP100678:1829787-1830119 [Salmonella enterica subsp. enterica serovar Anatum]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVIPVTSGGNFARAAGFTVSLEGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPDAVVNEVLARLEAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9512.02 Da        Isoelectric Point: 4.4929

>AT250970 WP_023243733.1 NZ_CP100678:1829529-1829786 [Salmonella enterica subsp. enterica serovar Anatum]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMREEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Z3IR43

Antitoxin

Source ID Structure
AlphaFold DB A0A618JW87

References