Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 979800..980614 | Replicon | chromosome |
| Accession | NZ_CP100678 | ||
| Organism | Salmonella enterica subsp. enterica serovar Anatum strain R17.0809 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A623LUR5 |
| Locus tag | NL708_RS04700 | Protein ID | WP_023243184.1 |
| Coordinates | 979800..980327 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | NL708_RS04705 | Protein ID | WP_000855694.1 |
| Coordinates | 980324..980614 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL708_RS04670 (976002) | 976002..976400 | + | 399 | Protein_914 | cytoplasmic protein | - |
| NL708_RS04675 (976591) | 976591..976830 | + | 240 | Protein_915 | hypothetical protein | - |
| NL708_RS04680 (976987) | 976987..977655 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| NL708_RS04685 (977682) | 977682..978176 | + | 495 | WP_000424947.1 | hypothetical protein | - |
| NL708_RS04690 (978421) | 978421..979077 | - | 657 | WP_023243186.1 | protein-serine/threonine phosphatase | - |
| NL708_RS04695 (979307) | 979307..979727 | + | 421 | Protein_919 | transposase | - |
| NL708_RS04700 (979800) | 979800..980327 | - | 528 | WP_023243184.1 | GNAT family N-acetyltransferase | Toxin |
| NL708_RS04705 (980324) | 980324..980614 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| NL708_RS04710 (980884) | 980884..981084 | - | 201 | Protein_922 | IS3 family transposase | - |
| NL708_RS04715 (981487) | 981487..981930 | - | 444 | WP_000715099.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| NL708_RS04720 (982388) | 982388..983038 | + | 651 | WP_001728903.1 | type III secretion system transcriptional activator InvF | - |
| NL708_RS04725 (983035) | 983035..984723 | + | 1689 | WP_023244646.1 | type III secretion system outer membrane ring protein InvG | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 979533..981084 | 1551 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19121.98 Da Isoelectric Point: 9.0946
>T250969 WP_023243184.1 NZ_CP100678:c980327-979800 [Salmonella enterica subsp. enterica serovar Anatum]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTWLALDNSDVTLIHGFYSVSPASLIYAQVPDAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTWLALDNSDVTLIHGFYSVSPASLIYAQVPDAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT250969 WP_000855694.1 NZ_CP100678:c980614-980324 [Salmonella enterica subsp. enterica serovar Anatum]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A623LUR5 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |