Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 832364..832989 Replicon chromosome
Accession NZ_CP100678
Organism Salmonella enterica subsp. enterica serovar Anatum strain R17.0809

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NL708_RS04035 Protein ID WP_000911337.1
Coordinates 832591..832989 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M7S3S8
Locus tag NL708_RS04030 Protein ID WP_000557549.1
Coordinates 832364..832591 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL708_RS04000 (827428) 827428..828526 + 1099 WP_010989230.1 peptide chain release factor 2 -
NL708_RS04005 (828536) 828536..830053 + 1518 WP_000003339.1 lysine--tRNA ligase -
NL708_RS04010 (830129) 830129..830674 - 546 WP_000133994.1 isopentenyl-diphosphate Delta-isomerase -
NL708_RS04015 (830939) 830939..831697 + 759 WP_000244328.1 amidase activator ActS -
NL708_RS04025 (831943) 831943..832155 - 213 WP_024149321.1 endonuclease -
NL708_RS04030 (832364) 832364..832591 + 228 WP_000557549.1 toxin-antitoxin system antitoxin VapB Antitoxin
NL708_RS04035 (832591) 832591..832989 + 399 WP_000911337.1 tRNA(fMet)-specific endonuclease VapC Toxin
NL708_RS04040 (833795) 833795..834331 + 537 WP_001038500.1 STM3031 family outer membrane protein -
NL708_RS04045 (834378) 834378..835010 + 633 WP_000835264.1 YfdX family protein -
NL708_RS04050 (835729) 835729..836310 + 582 WP_023243212.1 fimbrial protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 831943..842167 10224


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-123)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15037.43 Da        Isoelectric Point: 7.7785

>T250968 WP_000911337.1 NZ_CP100678:832591-832989 [Salmonella enterica subsp. enterica serovar Anatum]
MLKFMLDTNTCIFTIKNKPEHIRERFNLNTSRMCISSITLMELIYGAEKSLAPERNLAVVEGFISRLEVLDYDTQAAIHT
GQIRAELARKGTPVGPYDQMIAGHARSRGLVVVTNNLREFERIPGIRIEDWC

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8514.51 Da        Isoelectric Point: 5.0210

>AT250968 WP_000557549.1 NZ_CP100678:832364-832591 [Salmonella enterica subsp. enterica serovar Anatum]
MHTTLFFSNRTQAVRLPKSISFPEDVKHVEIIAVGRSRIITPVGESWDSWFDGEGASTDFMSTREQPAVQEREGF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
PDB 6IFM
AlphaFold DB A0A3V2Y5V5

References