Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 211690..212450 | Replicon | chromosome |
| Accession | NZ_CP100678 | ||
| Organism | Salmonella enterica subsp. enterica serovar Anatum strain R17.0809 | ||
Toxin (Protein)
| Gene name | tacT | Uniprot ID | Q57IH1 |
| Locus tag | NL708_RS00995 | Protein ID | WP_000533909.1 |
| Coordinates | 211965..212450 (+) | Length | 162 a.a. |
Antitoxin (Protein)
| Gene name | tacA | Uniprot ID | M7RHS4 |
| Locus tag | NL708_RS00990 | Protein ID | WP_000965886.1 |
| Coordinates | 211690..211977 (+) | Length | 96 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NL708_RS00970 (207095) | 207095..208006 | + | 912 | WP_001168551.1 | glycine--tRNA ligase subunit alpha | - |
| NL708_RS00975 (208016) | 208016..210085 | + | 2070 | WP_020437730.1 | glycine--tRNA ligase subunit beta | - |
| NL708_RS00980 (210475) | 210475..210873 | + | 399 | Protein_194 | IS3 family transposase | - |
| NL708_RS00985 (211045) | 211045..211512 | + | 468 | WP_000702452.1 | GNAT family N-acetyltransferase | - |
| NL708_RS00990 (211690) | 211690..211977 | + | 288 | WP_000965886.1 | DUF1778 domain-containing protein | Antitoxin |
| NL708_RS00995 (211965) | 211965..212450 | + | 486 | WP_000533909.1 | GNAT family N-acetyltransferase | Toxin |
| NL708_RS01000 (212821) | 212821..213360 | - | 540 | WP_000047140.1 | copper-binding periplasmic metallochaperone CueP | - |
| NL708_RS01005 (213535) | 213535..213747 | - | 213 | WP_000014594.1 | RNA chaperone/antiterminator CspA | - |
| NL708_RS01010 (214035) | 214035..214325 | - | 291 | WP_000455790.1 | HTH-type transcriptional regulator | - |
| NL708_RS01015 (214764) | 214764..215474 | + | 711 | WP_000190524.1 | DUF3053 domain-containing protein | - |
| NL708_RS01020 (215524) | 215524..216498 | - | 975 | WP_000804693.1 | glyoxylate/hydroxypyruvate reductase GhrB | - |
| NL708_RS01025 (216717) | 216717..217379 | - | 663 | WP_000747548.1 | OmpA family lipoprotein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 162 a.a. Molecular weight: 17703.41 Da Isoelectric Point: 9.8719
>T250965 WP_000533909.1 NZ_CP100678:211965-212450 [Salmonella enterica subsp. enterica serovar Anatum]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q
Download Length: 486 bp
Antitoxin
Download Length: 96 a.a. Molecular weight: 10950.60 Da Isoelectric Point: 4.6811
>AT250965 WP_000965886.1 NZ_CP100678:211690-211977 [Salmonella enterica subsp. enterica serovar Anatum]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV
Download Length: 288 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| PDB | 7F36 | |
| PDB | 7AK8 | |
| PDB | 5FVJ |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V2JDX2 |