Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 4234502..4235293 Replicon chromosome
Accession NZ_CP100670
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag NL713_RS20555 Protein ID WP_000369560.1
Coordinates 4234502..4235020 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag NL713_RS20560 Protein ID WP_001275017.1
Coordinates 4235024..4235293 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL713_RS20530 (4229567) 4229567..4230334 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
NL713_RS20535 (4230331) 4230331..4231608 - 1278 WP_000803764.1 branched chain amino acid ABC transporter permease LivM -
NL713_RS20540 (4231605) 4231605..4232531 - 927 WP_000003007.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
NL713_RS20545 (4232591) 4232591..4233700 - 1110 WP_000822976.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
NL713_RS20550 (4234122) 4234122..4234505 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
NL713_RS20555 (4234502) 4234502..4235020 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
NL713_RS20560 (4235024) 4235024..4235293 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
NL713_RS20565 (4235471) 4235471..4236574 - 1104 WP_001528146.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
NL713_RS20570 (4236896) 4236896..4237750 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
NL713_RS20575 (4237996) 4237996..4239051 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
NL713_RS20580 (4239044) 4239044..4239712 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4222915..4239712 16797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T250961 WP_000369560.1 NZ_CP100670:c4235020-4234502 [Salmonella enterica subsp. enterica serovar Mbandaka]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT250961 WP_001275017.1 NZ_CP100670:c4235293-4235024 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References