250952

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2153061..2153583 Replicon chromosome
Accession NZ_CP100670
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag NL713_RS10350 Protein ID WP_000221345.1
Coordinates 2153061..2153345 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag NL713_RS10355 Protein ID WP_000885424.1
Coordinates 2153335..2153583 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL713_RS10330 (2149136) 2149136..2150644 - 1509 WP_017441357.1 FAD-dependent oxidoreductase -
NL713_RS10335 (2150689) 2150689..2151177 + 489 WP_017441356.1 MarR family winged helix-turn-helix transcriptional regulator -
NL713_RS10340 (2151370) 2151370..2152443 + 1074 WP_017441355.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
NL713_RS10345 (2152501) 2152501..2152890 - 390 WP_001652798.1 RidA family protein -
NL713_RS10350 (2153061) 2153061..2153345 - 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NL713_RS10355 (2153335) 2153335..2153583 - 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NL713_RS10360 (2153996) 2153996..2154349 - 354 WP_000418733.1 hypothetical protein -
NL713_RS10365 (2154352) 2154352..2154741 - 390 WP_017441353.1 hypothetical protein -
NL713_RS10370 (2155106) 2155106..2155222 + 117 Protein_2021 IS110 family transposase -
NL713_RS10375 (2155745) 2155745..2156077 + 333 WP_017441352.1 DUF1493 family protein -
NL713_RS10380 (2156350) 2156350..2157258 + 909 WP_077906523.1 hypothetical protein -
NL713_RS10385 (2157260) 2157260..2158040 - 781 Protein_2024 helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2151370..2162789 11419


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T250952 WP_000221345.1 NZ_CP100670:c2153345-2153061 [Salmonella enterica subsp. enterica serovar Mbandaka]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT250952 WP_000885424.1 NZ_CP100670:c2153583-2153335 [Salmonella enterica subsp. enterica serovar Mbandaka]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References