Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1152231..1152851 Replicon chromosome
Accession NZ_CP100670
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL713_RS05425 Protein ID WP_001280991.1
Coordinates 1152231..1152449 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL713_RS05430 Protein ID WP_000344807.1
Coordinates 1152477..1152851 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL713_RS05385 (1147456) 1147456..1148025 + 570 WP_000779801.1 YbaY family lipoprotein -
NL713_RS05390 (1148058) 1148058..1148447 - 390 WP_000961285.1 MGMT family protein -
NL713_RS05400 (1148678) 1148678..1150228 - 1551 WP_000213140.1 EAL domain-containing protein -
NL713_RS05405 (1150453) 1150453..1150713 + 261 WP_254520504.1 type B 50S ribosomal protein L31 -
NL713_RS05410 (1150719) 1150719..1150859 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL713_RS05415 (1150915) 1150915..1151385 - 471 WP_000136183.1 YlaC family protein -
NL713_RS05420 (1151501) 1151501..1152052 - 552 WP_001278793.1 maltose O-acetyltransferase -
NL713_RS05425 (1152231) 1152231..1152449 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NL713_RS05430 (1152477) 1152477..1152851 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL713_RS05435 (1153347) 1153347..1156496 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL713_RS05440 (1156519) 1156519..1157712 - 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T250951 WP_001280991.1 NZ_CP100670:c1152449-1152231 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT250951 WP_000344807.1 NZ_CP100670:c1152851-1152477 [Salmonella enterica subsp. enterica serovar Mbandaka]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References