Detailed information of TA system TA025095

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 803301..803936
• Replicon: chromosome
• Accession: NC_015061
• Organism: Rahnella sp. Y9602

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: H8NSH0
• Locus tag: RAHAQ_RS25975
• Protein ID: WP_013574084.1
• Coordinates: 803754..803936 (-)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: H8NSG9
• Locus tag: RAHAQ_RS03775
• Protein ID: WP_013574083.1
• Coordinates: 803301..803732 (-)
• Length: 144 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
RAHAQ_RS03750	798510..799964	-	1455	WP_013574078.1	efflux transporter outer membrane subunit	-
RAHAQ_RS03755	799988..800509	-	522	WP_013574079.1	transcriptional repressor MprA	-
RAHAQ_RS03760	800684..801022	-	339	WP_013574080.1	L-valine transporter subunit YgaH	-
RAHAQ_RS03765	801012..801773	-	762	WP_013574081.1	AzlC family ABC transporter permease	-
RAHAQ_RS03770	801948..803132	-	1185	WP_013574082.1	MFS transporter	-
RAHAQ_RS03775	803301..803732	-	432	WP_013574083.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
RAHAQ_RS25975	803754..803936	-	183	WP_013574084.1	type II toxin-antitoxin system HicA family toxin	Toxin
RAHAQ_RS03780	804053..805048	-	996	WP_013574085.1	glycine betaine/L-proline ABC transporter substrate-binding protein ProX	-
RAHAQ_RS03785	805073..806083	-	1011	WP_013574086.1	glycine betaine/L-proline ABC transporter substrate-binding protein ProX	-
RAHAQ_RS03790	806189..807388	-	1200	WP_013574087.1	glycine betaine/L-proline ABC transporter permease ProW	-
RAHAQ_RS03795	807385..808581	-	1197	WP_013574088.1	glycine betaine/L-proline ABC transporter ATP-binding protein ProV	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-60)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (11-137)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6646.89 Da
• Isoelectric Point: 11.1595

>T25095 WP_013574084.1 NC_015061:c803936-803754 [Rahnella sp. Y9602]
MKSTELIKALLAAGCELKRHRGGSHQIWWSPVTNKTFPVPHPKNDLPVGTLKSIRKMAGI

Nucleotide

• Length: 183 bp

>T25095 NC_015061:c803936-803754 [Rahnella sp. Y9602]
ATGAAATCAACGGAATTGATTAAAGCGCTGCTTGCAGCGGGTTGTGAACTCAAGCGTCACCGGGGAGGAAGTCATCAAAT
TTGGTGGTCACCTGTCACCAACAAAACCTTTCCCGTTCCCCACCCCAAAAATGATTTACCTGTGGGAACTCTCAAATCCA
TTAGAAAAATGGCAGGGATATGA

Antitoxin

Protein

• Length: 144 a.a.
• Molecular weight: 16317.52 Da
• Isoelectric Point: 4.4314

>AT25095 WP_013574083.1 NC_015061:c803732-803301 [Rahnella sp. Y9602]
MFFSVGLETPKDDKTAYGMVVPAFTAFDYGCFSAADTREEIAPMVREAILMTVEDLIESERFVVDDIFDAGHLVYAANPE
YADFDTWFLIDIDLSEFEGKAHRINISLPDTLIKRIDNKVKNHPSYRDRSHFLAMAARKELLT

Nucleotide

• Length: 432 bp

>AT25095 NC_015061:c803732-803301 [Rahnella sp. Y9602]
ATGTTCTTTTCAGTCGGTCTTGAAACACCAAAAGATGACAAAACCGCTTACGGTATGGTGGTACCTGCATTTACCGCGTT
TGATTACGGATGCTTCTCTGCAGCGGATACCCGTGAAGAAATCGCCCCTATGGTTCGCGAAGCCATCCTGATGACAGTAG
AAGATTTGATCGAAAGCGAACGCTTTGTTGTTGACGATATTTTTGATGCAGGCCATTTGGTGTATGCCGCTAATCCCGAA
TATGCCGACTTCGATACCTGGTTTTTGATTGATATTGATCTCTCGGAATTCGAAGGGAAAGCGCATCGAATCAATATTTC
GCTGCCTGACACCCTGATCAAACGCATTGATAATAAAGTTAAAAATCATCCGTCATATCGCGACCGCAGCCATTTTCTGG
CGATGGCCGCACGTAAAGAATTGCTGACCTGA

Structures

Toxin

• AlphaFold DB: H8NSH0

Antitoxin

• AlphaFold DB: H8NSG9