Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 303886..304667 Replicon chromosome
Accession NZ_CP100670
Organism Salmonella enterica subsp. enterica serovar Mbandaka strain R17.0904

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag NL713_RS01390 Protein ID WP_000625911.1
Coordinates 304176..304667 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag NL713_RS01385 Protein ID WP_001271379.1
Coordinates 303886..304179 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL713_RS01350 (300188) 300188..301093 + 906 WP_254520487.1 YjiK family protein -
NL713_RS01355 (301387) 301387..301581 - 195 WP_223195369.1 hypothetical protein -
NL713_RS01360 (301629) 301629..301728 - 100 Protein_258 hypothetical protein -
NL713_RS01365 (301748) 301748..301915 + 168 WP_071527476.1 ATP-binding cassette domain-containing protein -
NL713_RS01370 (301922) 301922..302209 - 288 WP_072103482.1 transcriptional regulator RtsB -
NL713_RS01375 (302206) 302206..303081 - 876 WP_017441228.1 AraC family transcriptional regulator -
NL713_RS01380 (303347) 303347..303568 - 222 WP_001595143.1 hypothetical protein -
NL713_RS01385 (303886) 303886..304179 + 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
NL713_RS01390 (304176) 304176..304667 + 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
NL713_RS01395 (304882) 304882..305130 + 249 Protein_265 IS481 family transposase -
NL713_RS01400 (305376) 305376..305633 - 258 WP_001112996.1 hypothetical protein -
NL713_RS01405 (306226) 306226..306510 + 285 WP_192917775.1 PapB/FocB family fimbrial expression transcriptional regulator -
NL713_RS01410 (306545) 306545..307084 + 540 WP_000721295.1 type 1 fimbrial protein -
NL713_RS01415 (307094) 307094..309532 + 2439 WP_017441226.1 F4 (K88) fimbrial usher FaeD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeC / faeD / faeE / faeF / faeH / faeI 302206..317160 14954


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T250942 WP_000625911.1 NZ_CP100670:304176-304667 [Salmonella enterica subsp. enterica serovar Mbandaka]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT250942 WP_001271379.1 NZ_CP100670:303886-304179 [Salmonella enterica subsp. enterica serovar Mbandaka]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References