Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4352933..4353693 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name tacT Uniprot ID A0A1R2W0C7
Locus tag NL709_RS21365 Protein ID WP_000533912.1
Coordinates 4352933..4353418 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag NL709_RS21370 Protein ID WP_000965886.1
Coordinates 4353406..4353693 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS21335 (4348005) 4348005..4348667 + 663 WP_000747548.1 OmpA family lipoprotein -
NL709_RS21340 (4348886) 4348886..4349860 + 975 WP_000804678.1 glyoxylate/hydroxypyruvate reductase GhrB -
NL709_RS21345 (4349910) 4349910..4350620 - 711 WP_000190524.1 DUF3053 domain-containing protein -
NL709_RS21350 (4351059) 4351059..4351349 + 291 WP_000455790.1 HTH-type transcriptional regulator -
NL709_RS21355 (4351637) 4351637..4351849 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
NL709_RS21360 (4352023) 4352023..4352562 + 540 WP_000047147.1 copper-binding periplasmic metallochaperone CueP -
NL709_RS21365 (4352933) 4352933..4353418 - 486 WP_000533912.1 GNAT family N-acetyltransferase Toxin
NL709_RS21370 (4353406) 4353406..4353693 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
NL709_RS21375 (4353871) 4353871..4354338 - 468 WP_000702452.1 GNAT family N-acetyltransferase -
NL709_RS21380 (4354510) 4354510..4354908 - 399 Protein_4170 IS3 family transposase -
NL709_RS21385 (4355298) 4355298..4357367 - 2070 WP_001291741.1 glycine--tRNA ligase subunit beta -
NL709_RS21390 (4357377) 4357377..4358288 - 912 WP_001168551.1 glycine--tRNA ligase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17731.46 Da        Isoelectric Point: 9.8719

>T250938 WP_000533912.1 NZ_CP100666:c4353418-4352933 [Salmonella enterica subsp. enterica serovar Enteritidis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEVTGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT250938 WP_000965886.1 NZ_CP100666:c4353693-4353406 [Salmonella enterica subsp. enterica serovar Enteritidis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1R2W0C7

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References