Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3834468..3836091 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag NL709_RS18850 Protein ID WP_000088046.1
Coordinates 3834766..3836091 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag NL709_RS18845 Protein ID WP_024136327.1
Coordinates 3834468..3834761 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS18820 (3830340) 3830340..3831581 + 1242 WP_001053338.1 VWA domain-containing protein -
NL709_RS18825 (3832144) 3832144..3832425 - 282 WP_254520351.1 hypothetical protein -
NL709_RS18830 (3832475) 3832475..3832666 - 192 WP_000398480.1 hypothetical protein -
NL709_RS18835 (3832758) 3832758..3833099 - 342 WP_001151575.1 hypothetical protein -
NL709_RS18840 (3833472) 3833472..3833864 + 393 WP_000341066.1 hypothetical protein -
NL709_RS18845 (3834468) 3834468..3834761 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
NL709_RS18850 (3834766) 3834766..3836091 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
NL709_RS18855 (3836152) 3836152..3836358 + 207 WP_000134171.1 hypothetical protein -
NL709_RS18860 (3836460) 3836460..3836870 + 411 WP_000985911.1 hypothetical protein -
NL709_RS18865 (3836951) 3836951..3837655 - 705 WP_001067858.1 IS6-like element IS26 family transposase -
NL709_RS18870 (3837886) 3837886..3838380 + 495 WP_000439335.1 TIGR00645 family protein -
NL709_RS18875 (3838687) 3838687..3839781 + 1095 Protein_3682 Tar ligand binding domain-containing protein -
NL709_RS18880 (3839847) 3839847..3840551 + 705 WP_001067858.1 IS6-like element IS26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T250935 WP_000088046.1 NZ_CP100666:3834766-3836091 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT250935 WP_024136327.1 NZ_CP100666:3834468-3834761 [Salmonella enterica subsp. enterica serovar Enteritidis]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References