Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1076673..1077293 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag NL709_RS05065 Protein ID WP_001280991.1
Coordinates 1076673..1076891 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag NL709_RS05070 Protein ID WP_000344807.1
Coordinates 1076919..1077293 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS05025 (1071896) 1071896..1072465 + 570 WP_000779802.1 YbaY family lipoprotein -
NL709_RS05030 (1072498) 1072498..1072887 - 390 WP_000961287.1 MGMT family protein -
NL709_RS05040 (1073118) 1073118..1074668 - 1551 WP_000213140.1 EAL domain-containing protein -
NL709_RS05045 (1074893) 1074893..1075153 + 261 WP_000801415.1 type B 50S ribosomal protein L31 -
NL709_RS05050 (1075159) 1075159..1075299 + 141 WP_001197749.1 type B 50S ribosomal protein L36 -
NL709_RS05055 (1075355) 1075355..1075825 - 471 WP_000136183.1 YlaC family protein -
NL709_RS05060 (1075943) 1075943..1076494 - 552 WP_001278793.1 maltose O-acetyltransferase -
NL709_RS05065 (1076673) 1076673..1076891 - 219 WP_001280991.1 HHA domain-containing protein Toxin
NL709_RS05070 (1076919) 1076919..1077293 - 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
NL709_RS05075 (1077789) 1077789..1080938 - 3150 WP_001132508.1 efflux RND transporter permease AcrB -
NL709_RS05080 (1080961) 1080961..1082154 - 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T250926 WP_001280991.1 NZ_CP100666:c1076891-1076673 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT250926 WP_000344807.1 NZ_CP100666:c1077293-1076919 [Salmonella enterica subsp. enterica serovar Enteritidis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References