Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 501187..501763 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name shpA Uniprot ID M7RG88
Locus tag NL709_RS02415 Protein ID WP_001131963.1
Coordinates 501187..501474 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID B5R9R5
Locus tag NL709_RS02420 Protein ID WP_000063142.1
Coordinates 501461..501763 (+) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS02400 (498054) 498054..499358 - 1305 WP_000863534.1 type I restriction-modification protein specificity subunit -
NL709_RS02405 (499348) 499348..499527 - 180 Protein_462 DNA methyltransferase -
NL709_RS02410 (499521) 499521..500777 - 1257 Protein_463 NERD domain-containing protein/DEAD/DEAH box helicase -
NL709_RS02415 (501187) 501187..501474 + 288 WP_001131963.1 BrnT family toxin Toxin
NL709_RS02420 (501461) 501461..501763 + 303 WP_000063142.1 BrnA antitoxin family protein Antitoxin
NL709_RS02425 (501838) 501838..502794 - 957 WP_000187843.1 GTPase -
NL709_RS02430 (502805) 502805..503008 - 204 WP_000460616.1 YbdD/YjiX family protein -
NL709_RS02435 (503103) 503103..505253 - 2151 WP_000379928.1 pyruvate/proton symporter BtsT -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11294.80 Da        Isoelectric Point: 9.5894

>T250923 WP_001131963.1 NZ_CP100666:501187-501474 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPMEFEWDANKAKSNLRKHGVRFEDAVLVFDDPRHLSRQERYENGEYRWQTLGLVHGIVVILVAHSVRFESGFEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11373.96 Da        Isoelectric Point: 10.1293

>AT250923 WP_000063142.1 NZ_CP100666:501461-501763 [Salmonella enterica subsp. enterica serovar Enteritidis]
MSMVKHKRGNASALSAQHEAELKALAKKSDDEIDYSDIPASEDGQWSEAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLREQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7VD7

Antitoxin

Source ID Structure
PDB 7VD7
AlphaFold DB A0A4D6PB01

References