Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 308708..309489 Replicon chromosome
Accession NZ_CP100666
Organism Salmonella enterica subsp. enterica serovar Enteritidis strain R18.1630

Toxin (Protein)


Gene name TacT2 Uniprot ID B5R980
Locus tag NL709_RS01410 Protein ID WP_000626100.1
Coordinates 308998..309489 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID B5R979
Locus tag NL709_RS01405 Protein ID WP_001110452.1
Coordinates 308708..309001 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NL709_RS01370 (304755) 304755..305660 + 906 WP_001268200.1 YjiK family protein -
NL709_RS01375 (305954) 305954..306085 - 132 Protein_261 hypothetical protein -
NL709_RS01380 (306197) 306197..306445 - 249 Protein_262 Ig-like domain-containing protein -
NL709_RS01385 (306444) 306444..306752 + 309 WP_072095651.1 ABC transporter ATP-binding protein -
NL709_RS01390 (306745) 306745..307032 - 288 WP_001541332.1 transcriptional regulator RtsB -
NL709_RS01395 (307029) 307029..307904 - 876 WP_000921676.1 AraC family transcriptional regulator -
NL709_RS01400 (308170) 308170..308391 - 222 WP_001576552.1 hypothetical protein -
NL709_RS01405 (308708) 308708..309001 + 294 WP_001110452.1 DUF1778 domain-containing protein Antitoxin
NL709_RS01410 (308998) 308998..309489 + 492 WP_000626100.1 GNAT family N-acetyltransferase Toxin
NL709_RS01415 (309737) 309737..310489 - 753 WP_000842433.1 non-specific acid phosphatase -
NL709_RS01420 (310589) 310589..310666 - 78 Protein_270 porin family protein -
NL709_RS01425 (311046) 311046..311120 + 75 Protein_271 helix-turn-helix domain-containing protein -
NL709_RS01435 (311391) 311391..311966 - 576 WP_001188509.1 transcriptional regulator -
NL709_RS01440 (312003) 312003..313706 - 1704 WP_000068885.1 protein-disulfide reductase DsbD -
NL709_RS01445 (313682) 313682..314029 - 348 WP_000887832.1 divalent cation tolerance protein CutA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(85-145)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17645.45 Da        Isoelectric Point: 7.7297

>T250920 WP_000626100.1 NZ_CP100666:308998-309489 [Salmonella enterica subsp. enterica serovar Enteritidis]
MISTPEPLHAGHILTPFCCGVDSIDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTSPGRFRRNMPDP
IPVVVLGRLAVDKSLHGQGVARALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFVPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10977.61 Da        Isoelectric Point: 8.6141

>AT250920 WP_001110452.1 NZ_CP100666:308708-309001 [Salmonella enterica subsp. enterica serovar Enteritidis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLVRLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A656IQ80

Antitoxin

Source ID Structure
PDB 7AK7
AlphaFold DB A0A5I1DGA4

References