Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicB(antitoxin)
Location 4730625..4731253 Replicon chromosome
Accession NZ_CP100660
Organism Pseudomonas fluorescens strain ZL22

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NLL86_RS21750 Protein ID WP_254481170.1
Coordinates 4731068..4731253 (-) Length 62 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NLL86_RS21745 Protein ID WP_254481169.1
Coordinates 4730625..4731050 (-) Length 142 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLL86_RS21720 (NLL86_21720) 4726234..4726728 + 495 WP_254481164.1 DUF6231 family protein -
NLL86_RS21725 (NLL86_21725) 4726731..4727207 + 477 WP_254481165.1 YchJ family protein -
NLL86_RS21730 (NLL86_21730) 4727210..4727686 + 477 WP_254481166.1 LEA type 2 family protein -
NLL86_RS21735 (NLL86_21735) 4727694..4727897 + 204 WP_254481167.1 SEC-C metal-binding domain-containing protein -
NLL86_RS21740 (NLL86_21740) 4728138..4730579 + 2442 WP_254481168.1 penicillin acylase family protein -
NLL86_RS21745 (NLL86_21745) 4730625..4731050 - 426 WP_254481169.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NLL86_RS21750 (NLL86_21750) 4731068..4731253 - 186 WP_254481170.1 type II toxin-antitoxin system HicA family toxin Toxin
NLL86_RS21755 (NLL86_21755) 4731550..4731891 + 342 WP_254481171.1 hypothetical protein -
NLL86_RS21760 (NLL86_21760) 4731996..4733012 + 1017 WP_254481172.1 ligase-associated DNA damage response exonuclease -
NLL86_RS21765 (NLL86_21765) 4733009..4734667 + 1659 WP_254481173.1 ATP-dependent DNA ligase -
NLL86_RS21770 (NLL86_21770) 4734766..4735881 + 1116 WP_254481174.1 M14 family metallopeptidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-62)


Sequences

Toxin        


Download         Length: 62 a.a.        Molecular weight: 7051.21 Da        Isoelectric Point: 10.8456

>T250917 WP_254481170.1 NZ_CP100660:c4731253-4731068 [Pseudomonas fluorescens]
MKYSEFRRWLRARGVTFVPAKGSHFKVYLGNRQTIFPDHGGKEIGEGLRRKILKDLGLSEC

Download         Length: 186 bp

Antitoxin


Download         Length: 142 a.a.        Molecular weight: 15603.96 Da        Isoelectric Point: 4.7969

>AT250917 WP_254481169.1 NZ_CP100660:c4731050-4730625 [Pseudomonas fluorescens]
MTFDYPVIIHREAGSVWISCPDVPEMSSAGDTEEEALFDAVDAMESALSFYVDQKIAIPLPAERSADLPVVRLPALTAAK
AALWNTMVEQKVSKTEMARRLGVNRPQVDRLVDLLHRSKIEQVEHALHVLGQRIELAVVTA

Download         Length: 426 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References