Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 4575519..4576776 Replicon chromosome
Accession NZ_CP100653
Organism Pseudomonas aeruginosa strain F13

Toxin (Protein)


Gene name - Uniprot ID -
Locus tag NLS69_RS21395 Protein ID WP_003449003.1
Coordinates 4575519..4576274 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag NLS69_RS21400 Protein ID WP_003086329.1
Coordinates 4576408..4576776 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLS69_RS21385 (NLS69_21385) 4570692..4573235 + 2544 WP_003140632.1 acyl-homoserine-lactone acylase QuiP -
NLS69_RS21390 (NLS69_21390) 4573390..4574751 - 1362 WP_003081943.1 DNA recombination protein RmuC -
NLS69_RS21395 (NLS69_21395) 4575519..4576274 - 756 WP_003449003.1 RES family NAD+ phosphorylase Toxin
NLS69_RS21400 (NLS69_21400) 4576408..4576776 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
NLS69_RS21405 (NLS69_21405) 4576849..4578135 - 1287 WP_003112529.1 FAD-binding oxidoreductase -
NLS69_RS21410 (NLS69_21410) 4578191..4579780 - 1590 WP_003123191.1 aldehyde dehydrogenase family protein -
NLS69_RS21415 (NLS69_21415) 4579859..4580335 + 477 WP_003112531.1 hypothetical protein -
NLS69_RS21420 (NLS69_21420) 4580338..4580613 - 276 WP_169057979.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28292.45 Da        Isoelectric Point: 7.7294

>T250911 WP_003449003.1 NZ_CP100653:c4576274-4575519 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMVVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGTAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT250911 WP_003086329.1 NZ_CP100653:c4576776-4576408 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References