Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 3654337..3655558 Replicon chromosome
Accession NZ_CP100653
Organism Pseudomonas aeruginosa strain F13

Toxin (Protein)


Gene name vapC Uniprot ID A0A0C7CS07
Locus tag NLS69_RS17095 Protein ID WP_003102740.1
Coordinates 3654980..3655558 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag NLS69_RS17090 Protein ID WP_003088112.1
Coordinates 3654337..3654891 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLS69_RS17065 (NLS69_17065) 3649905..3650456 + 552 WP_003102727.1 XRE family transcriptional regulator -
NLS69_RS17070 (NLS69_17070) 3650453..3650851 - 399 WP_023082958.1 NADH-quinone oxidoreductase subunit A -
NLS69_RS17075 (NLS69_17075) 3650864..3651187 - 324 WP_003102734.1 multidrug efflux SMR transporter -
NLS69_RS17080 (NLS69_17080) 3651518..3651979 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
NLS69_RS17085 (NLS69_17085) 3651984..3654179 + 2196 WP_004349295.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
NLS69_RS17090 (NLS69_17090) 3654337..3654891 + 555 WP_003088112.1 helix-turn-helix transcriptional regulator Antitoxin
NLS69_RS17095 (NLS69_17095) 3654980..3655558 + 579 WP_003102740.1 HD domain-containing protein Toxin
NLS69_RS17100 (NLS69_17100) 3655667..3656854 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
NLS69_RS17105 (NLS69_17105) 3656844..3659015 - 2172 WP_014603035.1 type I secretion system permease/ATPase -
NLS69_RS17110 (NLS69_17110) 3659005..3660282 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21869.70 Da        Isoelectric Point: 5.3655

>T250910 WP_003102740.1 NZ_CP100653:3654980-3655558 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAARRDA

Download         Length: 579 bp

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20454.63 Da        Isoelectric Point: 8.1590

>AT250910 WP_003088112.1 NZ_CP100653:3654337-3654891 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLEELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C7CS07

Antitoxin

Source ID Structure

References