Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 1653242..1654937 Replicon chromosome
Accession NZ_CP100653
Organism Pseudomonas aeruginosa strain F13

Toxin (Protein)


Gene name doc Uniprot ID Q9HYA0
Locus tag NLS69_RS07885 Protein ID WP_003112901.1
Coordinates 1653242..1654111 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q9HYA1
Locus tag NLS69_RS07890 Protein ID WP_003112902.1
Coordinates 1654104..1654937 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NLS69_RS07860 (NLS69_07860) 1649250..1650101 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
NLS69_RS07865 (NLS69_07865) 1650142..1651149 + 1008 WP_003112897.1 ABC transporter substrate-binding protein -
NLS69_RS07870 (NLS69_07870) 1651146..1651922 + 777 WP_003112898.1 ABC transporter permease -
NLS69_RS07875 (NLS69_07875) 1651928..1652689 + 762 WP_003112899.1 SDR family oxidoreductase -
NLS69_RS07880 (NLS69_07880) 1652703..1653233 + 531 WP_003112900.1 cupin domain-containing protein -
NLS69_RS07885 (NLS69_07885) 1653242..1654111 + 870 WP_003112901.1 alpha/beta hydrolase Toxin
NLS69_RS07890 (NLS69_07890) 1654104..1654937 + 834 WP_003112902.1 IclR family transcriptional regulator Antitoxin
NLS69_RS07895 (NLS69_07895) 1654924..1655721 + 798 WP_003112903.1 SDR family oxidoreductase -
NLS69_RS07900 (NLS69_07900) 1655714..1657396 + 1683 WP_003130114.1 thiamine pyrophosphate-binding protein -
NLS69_RS07905 (NLS69_07905) 1657407..1658210 + 804 WP_003130116.1 aspartate dehydrogenase -
NLS69_RS07910 (NLS69_07910) 1658222..1659706 + 1485 WP_003453562.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30403.60 Da        Isoelectric Point: 6.5894

>T250908 WP_003112901.1 NZ_CP100653:1653242-1654111 [Pseudomonas aeruginosa]
MNMAQTHTPVPNLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAACLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERFGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSSIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30877.26 Da        Isoelectric Point: 5.7725

>AT250908 WP_003112902.1 NZ_CP100653:1654104-1654937 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPERIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q9HYA0

Antitoxin

Source ID Structure
AlphaFold DB Q9HYA1

References